28-deoxonimbolide
28-deoxonimbolide Basic information
- Product Name:
- 28-deoxonimbolide
- Synonyms:
-
- 28-deoxonimbolide
- 2H,5H-Cyclopenta[b]furo[2',3',4':4,5]naphtho[2,3-d]furan-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-5-oxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cS)-
- CAS:
- 126005-94-5
- MF:
- C27H32O6
- MW:
- 452.54
- Mol File:
- 126005-94-5.mol
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28-deoxonimbolide Chemical Properties
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
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28-deoxonimbolide Usage And Synthesis
Uses
28-Deoxonimbolide is a nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways[1].
Definition
ChEBI: A limonoid isolated from Azadirachta indica.
target
Caspase
IC 50
Caspase-8; Caspase-9; Caspase-3
References
[1] Kikuchi T, et al. Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem). J Nat Prod. 2011 Apr 25;74(4):866-70. DOI:10.1021/np100783k
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