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5-Nitrosalicylic acid

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5-Nitrosalicylic acid Basic information

Product Name:
5-Nitrosalicylic acid
Synonyms:
  • 2-hydroxy-5-nitro-benzoicaci
  • AURORA KA-2534
  • ANILOTIC ACID
  • 2-HYDROXY-5-NITROBENZOIC ACID
  • RARECHEM AL BE 0192
  • TIMTEC-BB SBB006535
  • 5-NITROSALICYLIC ACID
  • 5-NITRO-2-HYDROXY-BENZOIC ACID
CAS:
96-97-9
MF:
C7H5NO5
MW:
183.12
EINECS:
202-548-8
Product Categories:
  • C7
  • Carbonyl Compounds
  • Organic acids
  • API intermediates
  • Carboxylic Acids
  • Phenyls & Phenyl-Het
  • FINE Chemical & INTERMEDIATES
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
Mol File:
96-97-9.mol
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5-Nitrosalicylic acid Chemical Properties

Melting point:
228-230 °C(lit.)
Boiling point:
316.77°C (rough estimate)
Density 
1,65 g/cm3
vapor pressure 
0Pa at 25℃
refractive index 
1.6280 (estimate)
storage temp. 
no restrictions.
solubility 
water: soluble1g in 1475ml(lit.)
form 
Liquid
pka
pK1:2.12 (25°C)
color 
Clear yellow-beige to orange-brown
Water Solubility 
Soluble in water 1g/1475ml .
Merck 
14,6631
BRN 
2213719
InChIKey
PPDRLQLKHRZIJC-UHFFFAOYSA-N
LogP
1.158 at 25℃
CAS DataBase Reference
96-97-9(CAS DataBase Reference)
EPA Substance Registry System
Benzoic acid, 2-hydroxy-5-nitro- (96-97-9)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29182990

MSDS

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5-Nitrosalicylic acid Usage And Synthesis

Chemical Properties

yellow powder

Uses

5-Nitrosalicylic Acid is a salicylic acid derivative with anti-inflammatory effect against colitis.

Definition

ChEBI: A monohydroxybenzoic acid in which the hydroxy group is ortho- to the carboxylic acid group and which has a nitro substituent para- to the phenolic hydroxy group.

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 2377, 1995 DOI: 10.1016/0040-4039(95)00281-G

General Description

2-Hydroxy-5-nitrobenzoic acid inhibits the activity of wild type-bovine low Mr protein tyrosine phosphatase. The inhibition constant has been evaluated.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise the acid from Me2CO (charcoal), then twice more from Me2CO alone, aqueous EtOH (m 234-236o) or H2O (m 232-233o). [Beilstein 10 III 197, 10 IV 255.]

5-Nitrosalicylic acid Preparation Products And Raw materials

Preparation Products

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