6-hydroxydexamethasone Chemical Properties

Melting point:

259-262°C

Boiling point:

613.2±55.0 °C(Predicted)

Density 

1.38±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Dioxane (Very Slightly, Sonicated), Methanol (Slightly)

form 

Solid

pka

12.06±0.70(Predicted)

color 

White to Light Yellow

6-hydroxydexamethasone Usage And Synthesis

Description

6β-hydroxy Dexamethasone is a metabolite of dexamethasone (Item Nos. 11015 | 20340) that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans. The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.

Chemical Properties

Off-White Solid

Uses

The hydrophilic metabolite of Dexamethasone (D298800).

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