berberrubine
berberrubine Basic information
- Product Name:
- berberrubine
- Synonyms:
-
- 5,6-Dihydro-9-hydroxy-10-methoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride
- 9-Berberoline chloride
- 9-Demethoxy-9-hydroxyberberinium chloride
- Berberrubine chloride
- Beroline chloride
- berberrubine
- Chileninone
- Nerberrubine
- CAS:
- 15401-69-1
- MF:
- C19H16ClNO4
- MW:
- 357.78764
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 15401-69-1.mol
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berberrubine Chemical Properties
- Melting point:
- 245℃ (DEC.)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White to Dark Yellow
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C19H15NO4.ClH/c1-22-16-3-2-11-6-15-13-8-18-17(23-10-24-18)7-12(13)4-5-20(15)9-14(11)19(16)21;/h2-3,6-9H,4-5,10H2,1H3;1H
- InChIKey
- GYFSYEVKFOOLFZ-UHFFFAOYSA-N
- SMILES
- [Cl-].O1C([H])([H])OC2=C1C([H])=C1C(=C2[H])C2C([H])=C3C([H])=C([H])C(=C(C3=C([H])[N+]=2C([H])([H])C1([H])[H])O[H])OC([H])([H])[H]
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berberrubine Usage And Synthesis
Chemical Properties
Soluble in acidic solution, insoluble in petroleum ether, chloroform and other solvents. Derived from the roots of Thalictrum polygamun Muhl.
Uses
Berberrubine Chloride is a novel alkaloid with novel nitric-oxide donating activity. Antitumor and an antimicrobial agent.
Definition
ChEBI: Berberrubine is an alkaloid.
in vivo
Berberrubine (oral administration; 10-20 mg/kg; 7 days) has a beneficial effect in a mouse colitis model[3].
| Animal Model: | DSS (HY-116282) treated male Balb/c mice aged 6 weeks old[3] |
| Dosage: | 10 and 20 mg/kg |
| Administration: | Oral administration (p.o.); 7 days |
| Result: | Significantly reduced the disease activity index (DAI) with prolonged colon length and increased bodyweight at dose of 20 mg/kg. Significantly ameliorated the DSS-induced colonic pathological alternations and decreased histological scores. Markedly attenuated colonic inflammation by alleviating inflammatory cell infiltration and inhibiting myeloperoxidase (MPO) and cytokines (TNF-α, IFN-γ, IL-1β, IL-6, IL-4 and IL-10) productions in DSS mice. Substantially upregulated the expression of tight junction proteins (zonula occludens-1, zonula occludens-2, claudin-1, occludin) and mRNA expression of mucins (mucin-1 and mucin-2), and decreased the Bax/Bcl-2 ratio. |
berberrubineSupplier
Chembest Research Laboratories Limited
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BeiJing Hwrk Chemicals Limted
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Adamas Reagent, Ltd.
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Dalian Meilun Biotech Co., Ltd.
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- 0411-62910999 13889544652
- sales@meilune.com