defibrotide
defibrotide Basic information
- Product Name:
- defibrotide
- Synonyms:
-
- defibrotide
- Dasovas
- Defibrinotide
- Fraction p
- Noravid
- Prociclide
- defibrotide USP/EP/BP
- Defibrotide Impurity 2
- CAS:
- 83712-60-1
- MW:
- 0
- EINECS:
- 202-303-5
- Mol File:
- Mol File
defibrotide Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
defibrotide Usage And Synthesis
Description
Defibrotide is an antithrornbotic, partially-depolymerized polydeoxyribonucleotide obtained from bovine lungs. It is reported to be useful in the treatment of myocardial and severe lower limb ischemia, renal failure due to thrombotic microangiopathy, and thrombophlebitis, and in the prophylaxis of deep vein thrombosis, possibly via PCI2 stimulation.
Originator
Crinos (Italy)
Uses
Defibrotide sodium is a complex mixture of single stranded polydeoxyribonucleotides. Defibrotide sodium has liver protection, anti-inflammatory, antithrombotic, profibrinolytic, and anti-ischemic properties. Defibrotide sodium can be used for sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) research[1].
brand name
NORAVID; PROCICLIDE
in vivo
Intracarotid (i.c.) administration of Defibrotide sodium (64 mg/kg bolus plus 64 mg/kg/h for 1 h) prior to i.c. thrombin (100 μg/kg) significantly reduces the ability of thrombin to induce cranial thromboembolism in rabbits[2].
Intravenous (i.v.) administration of thrombin (20 μg/kg) in rabbits induces a reversible accumulation of radiolabelled platelets into the thoracic circulation which is significantly reduced by i.v. administration of defibrotide (64 mg/kg bolus plus 64 mg/kg/h for 1 h) prior to i.v. thrombin[2].
Intravenous injection of human thrombin (1250 μg/kg) to mice induces death within the majority of animals which is significantly reduced by pretreatment with defibrotide (150-175 mg/kg, i.v.)[2].
References
[1] May T Aziz, et al. Defibrotide: An Oligonucleotide for Sinusoidal Obstruction Syndrome. Ann Pharmacother. 2018 Feb;52(2):166-174. DOI:10.1177/1060028017732586
[2] W Paul, et al. The effect of defibrotide on thromboembolism in the pulmonary vasculature of mice and rabbits and in the cerebral vasculature of rabbits. Br J Pharmacol. 1993 Dec;110(4):1565-71. DOI:10.1111/j.1476-5381.1993.tb14002.x
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