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Grepafloxacin

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Grepafloxacin Basic information

Product Name:
Grepafloxacin
Synonyms:
  • GREPAFLOXACIN
  • 1-Cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  • dl-Grepafloxacin
  • Grepafloxacin USP/EP/BP
  • Grepafloxacin/OPC-17116/dl-Grepafloxacin
CAS:
119914-60-2
MF:
C19H22FN3O3
MW:
359.39
EINECS:
631-454-3
Mol File:
119914-60-2.mol
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Grepafloxacin Chemical Properties

Melting point:
189-192 ºC
Boiling point:
610.0±55.0 °C(Predicted)
Density 
1.366
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
6.44±0.50(Predicted)
color 
Pale Beige to Pale Yellow
Stability:
Hygroscopic
CAS DataBase Reference
119914-60-2(CAS DataBase Reference)
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Grepafloxacin Usage And Synthesis

Uses

dl-Grepafloxacin is an antibacterial compound used to treat various respirator infections.

Definition

ChEBI: Grepafloxacin is a member of quinolines, a quinolone antibiotic and a fluoroquinolone antibiotic.

in vivo

Grepafloxacin (OPC-17116; 200 mg/kg; p.o.; Balb/c mice) displays good safety profile in terms of phototoxicity[2].
Grepafloxacin (25-200 mg/kg; p.o.; 5 days/week for 4 weeks; female C57BL6/J-Lyst bg-J/ mice/beige mice) has modest activities in both intranasal (IN) infection and intravenous (IV) Mycobacterium aviuminfection models[3].

Animal Model:Female Balb/c mice (5-6 weeks)[2]
Dosage:200 mg/kg
Administration:Oral administration; once
Result:Had mild and short-lived erythema and no changed auricular thickness.
Animal Model:Female C57BL6/J-Lyst bg-J/ mice/beige mice with mycobacterium avium infection[3]
Dosage:25, 50, 100, and 200 mg/kg
Administration:Oral administration; 5 days/week for 4 weeks
Result:Had bactericidal activity and limited the growth of the bacteria.

IC 50

Quinolone

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