1-acetyl-3,2-toluyl-5-fluorouracil
1-acetyl-3,2-toluyl-5-fluorouracil Basic information
- Product Name:
- 1-acetyl-3,2-toluyl-5-fluorouracil
- Synonyms:
-
- 1-acetyl-3,2-toluyl-5-fluorouracil
- 1-Acetyl-3-o-toluyl-5-fluorouracil
- A-?OT-?Fu
- 2,4(1H,3H)-Pyrimidinedione, 1-acetyl-5-fluoro-3-(2-methylbenzoyl)-
- 1 Acetyl 3 o toluyl 5 fluorouracil,1Acetyl3otoluyl5fluorouracil
- CAS:
- 71861-76-2
- MF:
- C14H11FN2O4
- MW:
- 290.25
- Mol File:
- 71861-76-2.mol
1-acetyl-3,2-toluyl-5-fluorouracil Chemical Properties
- Melting point:
- 141-143 °C(Solv: ethyl ether (60-29-7))
- Boiling point:
- 408.8±55.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- -5.29±0.40(Predicted)
1-acetyl-3,2-toluyl-5-fluorouracil Usage And Synthesis
Uses
1-Acetyl-3-o-toluyl-5-fluorouracil is a potent antitumor agent and a 5-fluorouracil analog.
in vivo
Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d)[1].
References
[1] Yata N, et al. Anti-tumor activity of 1-acetyl-3-o-toluyl-5-fluorouracil against murine hepatoma MH134 and its effects on tissue weights following subcutaneous and oral administration. J Pharmacobiodyn. 1985 Apr;8(4):264-9. DOI:10.1248/bpb1978.8.264
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