FPL 62064
FPL 62064 Basic information
- Product Name:
- FPL 62064
- Synonyms:
-
- 1H-Pyrazol-3-amine,N-(4-methoxyphenyl)-1-phenyl-
- FPL 62064
- N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
- Cyclooxygenase,FPL 62064,LOX,5-lipoxygenase,FPL62064,inhibit,FPL-62064,Prostaglandin,5-LOX,COX,Inhibitor,synthetase,Lipoxygenase,anti-inflammatory,COX-2
- FPL 62064, 10 mM in DMSO
- CAS:
- 103141-09-9
- MF:
- C16H15N3O
- MW:
- 265.31
- Mol File:
- 103141-09-9.mol
FPL 62064 Chemical Properties
- Boiling point:
- 442.6±25.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO: 250 mg/mL (942.29 mM)
- pka
- 2.42±0.50(Predicted)
- form
- Solid
- color
- Light yellow to yellow
FPL 62064 Usage And Synthesis
Uses
FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity[1][2].
in vivo
FPL 62064 (5-20 mg/kg; intraperitoneal injection; female LACA mice) treatment inhibits peritoneal inflammation induced by immune-complex[1].
| Animal Model: | Female LACA mice (20-30 g) injected with immune complex[1]. |
| Dosage: | 5 mg/kg, 10 mg/kg, 20 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Produced a dose-related inhibition of dye extravasation, leukotriene C4 (LTC4) and prostaglandin E2 (PGE2) formation. |
References
[1] Blackham A, et al. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42. DOI:10.1007/BF01966309
[2] Shabaan MA, et al. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Arch Pharm (Weinheim). 2020 Feb 7:e1900308. DOI:10.1002/ardp.201900308
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