harzianic acid Chemical Properties

Melting point:

85-86 °C(Solv: ethyl acetate (141-78-6))

Boiling point:

619.6±55.0 °C(Predicted)

Density 

1.225±0.06 g/cm3(Predicted)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

pka

3.75±0.32(Predicted)

harzianic acid Usage And Synthesis

Description

Harzianic acid is a Trichoderma secondary metabolite. Harzianic acid shows plant growth promotion activity. 3. Harzianic acid has antifungal activity and antibiotic activity against Pythium irregulare, Sclerotinia sclerotiorum, and Rhizoctonia solani.

Uses

Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide[1][2].

target

Antifection

References

[1] De Filippis A, et al. Antimicrobial activity of harzianic acid against Staphylococcus pseudintermedius. Nat Prod Res. 2021 Dec;35(23):5440-5445. DOI:10.1080/14786419.2020.1779714
[2] Xie L, et al. Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase. J Am Chem Soc. 2021 Jun 16:10.1021/jacs.1c03988. DOI:10.1021/jacs.1c03988. doi: 10.1021/jacs.1c03988

harzianic acid(157148-06-6)Related Product Information

• harzianic acid
• 3-Pyrrolidin-2-yl-propionic acid
• 2-ISOPROPYL-5-OXOHEXANOICACID
• 1-METHYL-PYRROLIDINE-2,4-DIONE
• 2,4-Pyrrolidinedione
• 3,5,7-Nonatrien-2-one
• 2-HEXANONE, 3-AMINO-5-METHYL-
• 5-(2-HYDROXY-ETHYL)-PYRROLIDIN-2-ONE