Siltenzepine Chemical Properties

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

Siltenzepine Usage And Synthesis

Uses

Siltenzepine (AWD 26-06 free base) is an antagonist of mAChR with anti-acid activity, which can be used in peptic ulcers research. Siltenzepine exhibits rapidly but incompletely absorbed characterastic in rats (po)[1][2].

in vivo

References

[1] Pfeifer S, et al. Biotransformation und Pharmakokinetik von AWD 26-06, 8-Chlor-5,10-dihydro-5-[bis(2-hydroxyethyl)aminoacetyl]-11H- dibenzo[d,c][1,4]diazepin-11-on-hydrochlorid an der Ratte [Biotransformation and pharmacokinetics of AWD 26-06, 8-chloro-5,10-dihydro-5-[bis(2-hydroxyethyl)aminoacetyl]-11H-dibenzo[d, c][1,4]diazepin-11-one hydrochloride in the rat]. Pharmazie. 1990 Jul;45(8):603-7. German. PMID:2080209
[2] Trausch B, et al. The biliary and renal elimination of the new muscarinic-1-antagonist AWD 26-06 in volunteers with T-tube after cholecystectomy. Int J Clin Pharmacol Ther Toxicol. 1992 Nov;30(11):508-9. PMID:1490811

Siltenzepine(98374-54-0)Related Product Information

• 2-AMINO-4-CHLORODIPHENYLAMINE
• N-(2-aminophenyl)-2-(diethylamino)acetamide
• N1-(2-AMINOPHENYL)-N2,N2-DIMETHYLGLYCINAMIDE
• 2-AMINO-N-(3-CHLOROPHENYL)BENZAMIDE
• 5,10-DIHYDRO-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE
• 2-(2-HYDROXYETHYLAMINO)-N-(4-CHLOROPHENYL)ACETAMIDE
• 8-Chloro-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one
• N-(2-aminophenyl)-N-methyl-N-phenylamine
• 2-diethylamino-N,N-diphenyl-acetamide
• Siltenzepine