CORYNOLINE Chemical Properties

Melting point:

180～181℃

Boiling point:

504.2±50.0 °C(Predicted)

Density 

1.395±0.06 g/cm3(Predicted)

storage temp. 

Amber Vial, -20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly, Heated)

pka

14.14±0.40(Predicted)

form 

Solid

color 

Off-White to Pale Yellow

Stability:

Light Sensitive

InChI

InChI=1S/C21H21NO5/c1-21-14-3-4-15-19(27-10-24-15)13(14)8-22(2)20(21)12-7-17-16(25-9-26-17)5-11(12)6-18(21)23/h3-5,7,18,20,23H,6,8-10H2,1-2H3/t18-,20+,21-/m0/s1

InChIKey

IQUGPRHKZNCHGC-TYPHKJRUSA-N

SMILES

[C@@H]1(O)[C@@]2(C)[C@]([H])(N(C)CC3=C2C=CC2OCOC3=2)C2C=C3OCOC3=CC=2C1

Safety Information

Safety Statements 

24/25

HS Code 

29389090

CORYNOLINE Usage And Synthesis

Description

The empirical formula of corynoline should read C21H21NO5

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from bitter herb.

Uses

Corynoline is an isoquinoline alkaloid with reported pharmacological activity such as cell adhesion inhibition, sedation and liver protection.

Definition

ChEBI: A benzophenanthridine alkaloid that is chelidonine substituted by a methyl group at position 13. Isolated from the aerial parts of Corydalis incisa, it acts as an acetylcholinesterase inhibitor and also exhibits antineoplastic and hepatoprotec ive activity.

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