Diisopinocampheylborane Chemical Properties

Boiling point:

351.5±25.0 °C(Predicted)

storage temp. 

Hygroscopic, Refrigerator, under inert atmosphere

solubility 

Dichloromethane (Slightly), THF (Slightly)

form 

Solid

color 

White Sticky to Off-White

Stability:

Extremely Moisture Sensitive

Diisopinocampheylborane Usage And Synthesis

Chemical Properties

White Sticky Solid

Uses

Diisopinocampheylborane is a hydroborane with many applications in organic synthesis of nicotine analogs, (-)-Invictolide, (+)-strictifolione and other organic compounds.

Application

Diisopinocampheylborane is a chiral hydroboration reagent for asymmetric hydroboration of cis-alkenes to provide access to optically active secondary alcohols. It is a precursor for the preparation of a large number of chiral reagents for asymmetric synthesis.

Synthesis

(+)-diisopinocampheylborane is prepared in high enantiomeric purity and good yield (Table 1) by hydroboration of commercially available (-)-α-pinene (of low enantiomeric purity) with Borane-Dimethyl Sulfide (BMS) complex, carried out by mixing the two reagents to make a solution of known molarity in THF at 0 °C or rt (eq 1); the mixture is left without stirring at 0 °C for ~12 h for the development of crystals (the slow crystallization facilitates the incorporation of the major diastereomer in the crystalline product, leaving the undesired isomer in solution); the supernatant solution is decanted using a double-ended needle; the crystalline lumps are broken and washed with diethyl ether and dried under vacuum (~12 mmHg) at rt.

Precautions

Diisopinocampheylborane is air sensitive, reacting instantaneously with protic solvents to liberate hydrogen; must be handled under an inert atmosphere (N2 or Ar); can be stored at 0 °C under inert atmosphere for several months without loss of hydride activity.

Diisopinocampheylborane(21947-87-5)Related Product Information

• (-)-Diisopinocampheyl chloroborane
• 6-Chloroisatin
• Methoxydiethylborane
• (+)-Diisopinocampheyl chloroborane
• Borane-tetrahydrofuran complex
• Pentaborane
• Diborane
• ALPHA-PINENE
• (1R)-(+)-ALPHA-PINENE
• Diisopinocampheylborane