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2-Cyano-5-methoxypyridine

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2-Cyano-5-methoxypyridine Basic information

Product Name:
2-Cyano-5-methoxypyridine
Synonyms:
  • 5-methoxypyridine-2-carbonitrile
  • 5-Methoxy-2-Pyridinecarbonitrile
  • 2-Cyano-5-methoxypyridine, 5-Methoxypicolinonitrile
  • 5-Methoxypicolinonitrile
  • 2-PYRIDINECARBONITRILE, 5-METHOXY
  • 143224
  • 2-Cyano-5-methoxypyridine ISO 9001:2015 REACH
CAS:
89809-63-2
MF:
C7H6N2O
MW:
134.14
EINECS:
200-589-5
Mol File:
89809-63-2.mol
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2-Cyano-5-methoxypyridine Chemical Properties

Boiling point:
292.1±20.0 °C(Predicted)
Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
-4.06±0.10(Predicted)
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Safety Information

HS Code 
2933399990
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2-Cyano-5-methoxypyridine Usage And Synthesis

Synthesis

To a mixture of 2-cyano-5-hydroxy pyridine (200 mg, 1.66 mmol), DMF (10 mL) and K2CO3 (253 mg, 1.83 mmol), was added MeI (354 mg, 2.49 mmol) at room temperature and the reaction mix was stirred for 24 h at room temperature. The reaction mix was poured into water and extracted with ethyl acetate. The organic layer was separated, washed with water, dried and concentrated to give 2-Cyano-5-methoxypyridine (175 mg, 78% yield).

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