3-Bromo-4-hydroxy-5-nitropyridine Chemical Properties

Boiling point:

341.8±37.0 °C(Predicted)

Density 

2.006±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

-1.63±0.38(Predicted)

color 

White to Light yellow to Light orange

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933399990

3-Bromo-4-hydroxy-5-nitropyridine Usage And Synthesis

Synthesis

Step 1. Synthesis of 3-bromo-5-nitropyridin-4-ol To a suspension of 4-hydroxy-3-nitropyridine (7.00 g, 50 mmol) in water (50 mL), bromine (3.23 mL, 63 mmol) was added slowly and dropwise at room temperature. The reaction mixture was stirred at room temperature for 1 hour, followed by heating to 50 °C and maintained for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and stirring was continued for 1 hour. The solid product was collected by filtration, washed well with water and dried under vacuum for 2 days to afford 3-bromo-5-nitropyridin-4-ol 9.54 g in 87% yield.

References

[1] Patent: WO2005/37198, 2005, A2. Location in patent: Page/Page column 26
[2] Patent: WO2006/38773, 2006, A1. Location in patent: Page/Page column 57
[3] Patent: WO2005/37198, 2005, A2. Location in patent: Page/Page column 26
[4] Tetrahedron Letters, 2012, vol. 53, # 4, p. 377 - 379
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2462 - 2471

3-Bromo-4-hydroxy-5-nitropyridine(31872-65-8)Related Product Information

• Methyl 4-hydroxyquinoline-6-carboxylate
• 8-FLUORO-4-HYDROXYQUINOLINE
• 3,5-Diiodo-4-hydroxypyridine
• 4-Hydroxy-6-methoxyquinoline-3-carbonitrile
• 4-HYDROXY-5-BROMOQUINOLINE
• 4-Hydroxy-3-methyl-1H-indazole
• 4-HYDROXY-7-NITROQUINOLINE
• 1-Methylazepan-4-ol
• Benzaldehyde, 4-hydroxy-2-iodo-
• 3-iodopyridin-4-ol
• 5-hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
• 2-Pyridinecarboxylic acid, 4-hydroxy-, methyl ester (9CI)
• 5-IODO-1H-PYRIMIDIN-4-ONE
• 4-Hydroxy-2-pyridinecarboxylic acid ethyl ester
• 3-Bromo-4-hydroxy-5-nitropyridine
• 3-BROMO-2,6-DIMETHYL-5-NITROPYRIDIN-4-OL
• 2,3,6-TRIBROMO-4-METHOXY-5-NITROPYRIDINE
• 3-NITRO-4-HYDROXY-5-BROMOPYRIDINE N-OXIDE