N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE Chemical Properties

storage temp. 

-10 to -25°C

form 

Solid

color 

White to off-white

Water Solubility 

Soluble to 100 mM in water

N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE Usage And Synthesis

Uses

N1,N11-Diethylnorspermine Tetrahydrochloride is a polyamine analog binding to human serum albumin induce conformational transition and secondary structure change, a partial protein unfolding.

Biological Activity

DENSPM HCl is a nontoxic polyamine analog th at enhances polyamine catabolism and production of hazardous hydrogen peroxide and N-acetyl-3-aminopropanal by inducing spermidine/spermine-N1-acetyl transferase (SSAT) expression. DENSPM HCl improves stem cell maintenance through reduced translation, exhibits slower proliferation rates in cancer cells, and induces autophagy. It shows greater antitumor activity and less associated toxicity in a human melanoma xenograft model.

storage

Store at RT