2-Bromo-6-fluoronitrobenzene Chemical Properties

Melting point:

36-37°C

Boiling point:

232.0±20.0 °C(Predicted)

Density 

1.808±0.06 g/cm3(Predicted)

Flash point:

87°

storage temp. 

2-8°C

solubility 

soluble in Methanol

form 

powder to lump

color 

White to Orange to Green

InChI

InChI=1S/C6H3BrFNO2/c7-4-2-1-3-5(8)6(4)9(10)11/h1-3H

InChIKey

VFPAOFBPEYCAAZ-UHFFFAOYSA-N

SMILES

C1(Br)=CC=CC(F)=C1[N+]([O-])=O

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38

Safety Statements 

36

HazardClass 

IRRITANT

HS Code 

29042090

2-Bromo-6-fluoronitrobenzene Usage And Synthesis

Chemical Properties

light yellow crystalline powder

Uses

2-Bromo-6-fluoronitrobenzene is a hydrocarbon derivative, mainly used as an organic intermediate.

Reactions

The structure of 2-bromo-6-fluoronitrobenzene contains a nitro unit with high electron-withdrawing properties, which can easily undergo aromatic nucleophilic substitution reactions under the attack of common nucleophiles such as alcohols or amines.

Synthesis

To a suspension of sodium perborate tetrahydrate (135.374 g., 886.4 mmol) in 500 mL of acetic acid at 55??C was added dropwise 2-bromo-6-fluoroaniline (33.685 g., 177.271 mmol) in 70 mL solution in acetic acid. The reaction mixture was stirred at 55?? C. for an additional 3 h. and then cooled in an ice bath to 0?? C. Insoluble material was removed by filtration through a diatomaceous earth plug and washed with 100 mL of acetic acid. The combined acetic acid was added to 3 liters of ice water with stirring to give a waxy solid which was removed by filtration. The crude solid was dissolved in 250 mL of ethyl acetate and washed three times with 200 mL of 10% aqueous hydrogen chloride, 200 mL of saturated sodium bicarbonate, and 100 mL of brine. Concentrate the solution in vacuum to give 2-bromo-6-fluoronitrobenzene as a red oil in 11.51 g yield.

2-Bromo-6-fluoronitrobenzene(886762-70-5)Related Product Information

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