4,6-PYRIMIDINE DICARBOXYLIC ACID Chemical Properties

Melting point:

238-240℃

Boiling point:

497.4±30.0 °C(Predicted)

Density 

1.665±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

2.14±0.10(Predicted)

form 

solid

color 

White

Safety Information

HS Code 

2933599590

4,6-PYRIMIDINE DICARBOXYLIC ACID Usage And Synthesis

Uses

4,6-Pyrimidinedicarboxylic Acid is used in the preparation of inhibitor scaffolds that inhibit the human 2-oxoglutarate-dependent JMJD2 subfamily of histone demethylases.

Synthesis

General procedure for the synthesis of pyrimidine-4,6-dicarboxylic acid from dimethyl pyrimidine-4,6-dicarboxylate: To a solution of dimethyl pyrimidine-4,6-dicarboxylate (170 mg, 0.87 mmol) in methanol (5 mL) was added 1 N sodium hydroxide solution (5 mL, 5.00 mmol). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by evaporation and the resulting concentrated solution was acidified to pH 2-3 with 5 N hydrochloric acid.The resulting white precipitate was collected by filtration and washed with distilled water (2 mL) to give the final pyrimidine-4,6-dicarboxylic acid (125 mg, 86% yield).

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 22, p. 7053 - 7056
[2] Patent: WO2010/43866, 2010, A2. Location in patent: Page/Page column 77

4,6-PYRIMIDINE DICARBOXYLIC ACID(16490-02-1)Related Product Information

• DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE
• PyriMidine-5-carboxaMidine hydrochloride
• 5-AMINOPYRIMIDINE
• Pyrimidine-2-sulfonic acid pentafluorophenyl ester
• 4-Pyrimidinecarbonitrile (7CI,9CI)
• PYRIMIDINE-5-CARBOTHIOIC ACID AMIDE
• PYRIMIDINE-4-CARBOXYLIC ACID HYDRAZIDE
• Pyrimidine-5-carboxaldehyde
• Pyrimidine-2-carboxylic acid
• PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER
• Pyrimidine-5-boronic acid pinacol ester
• 5-PYRIMIDINECARBOXAMIDE
• 4-Pyrimidinecarboxylic acid
• PYRIMIDIN-4-YL-METHANOL
• 4,6-DIMETHYLPYRIMIDINE
• PYRIMIDINE-4-CARBOXALDEHYDE
• 4,6-PYRIMIDINE DICARBOXYLIC ACID