4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Chemical Properties

Melting point:

143 °C

Boiling point:

459.8±45.0 °C(Predicted)

Density 

1.305

vapor pressure 

0Pa at 20℃

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)

form 

Solid

pka

13.92±0.46(Predicted)

color 

Orange to Dark Red to Brown

Water Solubility 

190mg/L at 20℃

LogP

1.3 at 25℃

Safety Information

HS Code 

2933.39.9200

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Usage And Synthesis

Chemical Properties

4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide has the appearance of a white to yellow powder or crystals, which is stable and non-reactive under normal conditions of use, storage and transport.

Uses

4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide is a compound used as a reagent to synthesize Regorafenib (R143000), a multikinase inhibitor that is used to treat patients with advanced colorectal cancer.

Definition

ChEBI: 4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide is an aromatic ether.

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