2',5'-Dimethoxyacetophenone Chemical Properties

Melting point:

18-20 °C(lit.)

Boiling point:

155-158 °C11 mm Hg(lit.)

Density 

1.139 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.5441(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Methanol (Slightly)

form 

oily liquid

color 

Clear yellow to green-yellow

BRN 

2047423

InChIKey

FAXUIYJKGGUCBO-UHFFFAOYSA-N

LogP

2.125 (est)

CAS DataBase Reference

1201-38-3(CAS DataBase Reference)

NIST Chemistry Reference

Ethanone, 1-(2,5-dimethoxyphenyl)-(1201-38-3)

EPA Substance Registry System

Ethanone, 1-(2,5-dimethoxyphenyl)- (1201-38-3)

Safety Information

Hazard Codes 

Xi

Safety Statements 

24/25

WGK Germany 

3

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29145090

MSDS

• Language:English Provider:2',5'-Dimethoxyacetophenone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2',5'-Dimethoxyacetophenone Usage And Synthesis

Chemical Properties

clear yellow to green-yellow liquid

Uses

2'',5''-Dimethoxyacetophenone is a useful building block which has been used in the preparation of pyridine and thieno[2,3-b] pyridine derivatives as anticancer PIM-1 kinase inhibitors, and in the synthesis of anti-cancer and apoptosis-inducing agents.

Preparation

Obtained by reaction of dimethyl sulfate with quinacetophenone in the presence of 10% aqueous sodium hydroxide.

Synthesis

2',5'-Dimethoxyacetophenone is prepared from Hydroquinone dimethylether and Acetic anhydride with Aluminum chloride catalyst.

2',5'-Dimethoxyacetophenone(1201-38-3)Related Product Information

• Glycitein
• 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE
• 2',5'-Dimethoxyacetophenone
• KHELLIN
• 6-METHOXYLUTEOLIN
• SCUTELLAREIN TETRAMETHYL ETHER
• Tangeretin
• 4',6,7-Trimethoxyisoflavone
• 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE
• 2-BROMO-2',5'-DIMETHOXYACETOPHENONE,A-BROMO-2',5'-DIMETHOXYACETOPHENONE
• 3',4',5',6,7,8-HEXAMETHOXY-5-HYDROXYFLAVONE
• EUPATORIN-5-METHYL ETHER
• 2'-HYDROXY-4',5'-DIMETHOXYACETOPHENONE
• 6-HYDROXY-2,4-DIMETHOXYACETOPHENONE,2-HYDROXY-4,6-DIMETHOXYACETOPHENONE,2'-HYDROXY-4',6'-DIMETHOXYACETOPHENONE
• 2'-AMINO-4',5'-DIMETHOXYACETOPHENONE,2-AMINO-4,5-DIMETHOXYACETOPHENONE
• 2-Hydroxy-3-iodo-4,6-dimethoxy acetophenone
• 2',6'-DIMETHOXYACETOPHENONE,2,6-DIMETHOXYACETOPHENONE
• 2,2,2-TRIFLUORO-2',4'-DIMETHOXYACETOPHENONE