4-ISOBUTOXY-BENZALDEHYDE Chemical Properties

Melting point:

155℃

Boiling point:

74°C/0.08mm

Density 

1.018±0.06 g/cm3 (20 ºC 760 Torr)

refractive index 

1.5344 (589.3 nm 20℃)

Flash point:

118.9±13.4℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Oil

color 

Pale Yellow

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2912490090

4-ISOBUTOXY-BENZALDEHYDE Usage And Synthesis

Uses

4-Isobutoxybenzaldehyde to treat neurodegenerative diseases.

Synthesis

Step 2: Preparation of 4-isobutoxybenzaldehyde (Compound XIII) 4-Hydroxybenzaldehyde (10 g, 0.082 mol), potassium carbonate (33.95 g, 0.246 mol) and potassium iodide (1.36 g, 0.008 mol) were suspended in N,N-dimethylformamide (50 mL). Isobutyl bromide (26.7 mL, 0.246 mol) was added to the suspension and the reaction was subsequently heated at 70 °C and protected by nitrogen for 3 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with 150 mL of water and then extracted with 300 mL of ethyl acetate. The organic phase was washed five times with 150 mL of 10% NaCl solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 14.3 g (98% yield) of the yellow oily product 4-isobutoxybenzaldehyde (Compound XIII).

References

[1] Patent: US2018/37549, 2018, A1. Location in patent: Paragraph 0151
[2] Patent: CN105418460, 2016, A. Location in patent: Paragraph 0053; 0056; 0057; 0058; 0059
[3] Patent: CN108358817, 2018, A. Location in patent: Paragraph 0055; 0056; 0057
[4] Russian Journal of General Chemistry, 2005, vol. 75, # 7, p. 1113 - 1124
[5] Patent: WO2006/36874, 2006, A1. Location in patent: Page/Page column 21

4-ISOBUTOXY-BENZALDEHYDE(18962-07-7)Related Product Information

• 4-(2-Methylpropoxy)-1,3-benzenedicarbothioaMide
• Febuxostat Impurity 8
• isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
• ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
• ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
• 3-Cyano-4-isobutoxybenzoic acid
• FeBuxostat Impurity 33
• Febuxostat impurity 37
• Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
• Febuxostat-d9
• 2-[3-(AMinocarbonyl)-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
• 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
• 2-HYDROXY-THIOBENZAMIDE
• 3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide
• Febuxostat Impurity 6
• 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid
• Febuxostat Impurity 14
• Febuxostat Bromo Impurity