Jaceosidin
Jaceosidin Basic information
- Product Name:
- Jaceosidin
- Synonyms:
-
- JACEOSIDIN
- 3',6-Dimethoxy-4',5,7-trihydroxyflavone
- 5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
- 6-Hydroxyluteolin 3',6-dimethyl ether
- Jacesiolin
- 4',5,7-Trihydroxy-3',6-dimethoxyflavone
- 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-
- 5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one
- CAS:
- 18085-97-7
- MF:
- C17H14O7
- MW:
- 330.29
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 18085-97-7.mol
Jaceosidin Chemical Properties
- Melting point:
- 259-260 °C
- Boiling point:
- 619.0±55.0 °C(Predicted)
- Density
- 1.483±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated), Pyridine (Slightly)
- form
- Solid
- pka
- 6.47±0.40(Predicted)
- color
- Pale Yellow to Light Yellow
- Stability:
- Hygroscopic
- Major Application
- food and beverages
- InChI
- InChI=1S/C17H14O7/c1-22-13-5-8(3-4-9(13)18)12-6-10(19)15-14(24-12)7-11(20)17(23-2)16(15)21/h3-7,18,20-21H,1-2H3
- InChIKey
- GLAAQZFBFGEBPS-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=C(O)C(OC)=C2)OC2=CC(O)=C(OC)C(O)=C2C(=O)C=1
- LogP
- 1.300 (est)
Jaceosidin Usage And Synthesis
Chemical Properties
Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from the leaves of Ailanthus, long-leaved arnica flowers, silver artemisia above ground, stevia, the leaves of the ground yellow, the above ground parts of the vine.
Uses
Jaceosidin exhibits anti-allergic, anti-inflammatory and apoptosis inducing activities.
Definition
ChEBI: A trihydroxyflavone that is flavone with hydroxy groups at positions 5, 7 and 4' and methoxy groups at positions 3' and 6. Isolated from Salvia tomentosa and Artemisia asiatica, it exhibits anti-allergic, anti-inflammatory and apo tosis inducing activties.
in vivo
Jaceosidin (10 and 20 mg/kg, p.o., once a day for 3 days) blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates in mice[3].
?
Jaceosidin (10, 20 mg/kg, p.o.) suppresses COX-2 expression and NF-κB activation in mice[3].
?
Jaceosidin (20 mg/kg, p.o. for 2 hours) reduces hind paw edema volume in rats[3].
| Animal Model: | 5-week-old male BALB/c mice (23-26 g)[3] |
| Dosage: | 10 and 20 mg/kg |
| Administration: | P.O. once a day for 3 days |
| Result: | Decreased the volumes of exudates (inflammatory markers), cell number and protein levels. Inhibited TNF-α by 46.7% and 50.8%, IL-1β by 46.0% and 44.7%, and PGE2 by 21.7% and 16.9%, respectively, at 20 mg/kg. Blocked COX-2 expression and NF-κB activation. |
| Animal Model: | Male Sprague-Dawley rats (180-200 g)[3] |
| Dosage: | 20 mg/kg |
| Administration: | P.O., for 2 hour |
| Result: | Reduced hind paw edema volume by 27.1% at 1 h, and 24.0% at 2 h, respectively. |
IC 50
Bax; COX-2
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