7-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one Chemical Properties

Boiling point:

403.9±45.0 °C(Predicted)

Density 

1.772

storage temp. 

Sealed in dry,Room Temperature

pka

9.98±0.20(Predicted)

Appearance

White to off-white Solid

7-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one Usage And Synthesis

Synthesis

General procedure for the synthesis of 7-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones from 2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones: to 2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones (1 g, 6.66 mmol) of N,N-dimethylformamide (DMF. 30 mL) solution was slowly added bromine (0.480 mL, 9.32 mmol) dropwise. The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, deionized water was added to induce precipitate formation and the precipitate was collected by filtration. The resulting solid was dried overnight in a freeze dryer to afford 7-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (1.16 g, 76% yield). The product was characterized by 1H NMR (DMSO-d6): δ 11.43 (s, 1H), 8.04 (d, J = 2.0 Hz, 1H), 7.65 (d, J = 2.0 Hz, 1H), 4.67 (s, 2H).

References

[1] Bioorganic and Medicinal Chemistry, 1998, vol. 6, # 2, p. 133 - 142
[2] Patent: WO2009/100536, 2009, A1. Location in patent: Page/Page column 93-94
[3] Patent: WO2006/113432, 2006, A2. Location in patent: Page/Page column 56-57
[4] Patent: US4906629, 1990, A
[5] Patent: US4822794, 1989, A

7-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one(122450-96-8)Related Product Information

• 5-BROMO-3-METHOXYPYRIDIN-2-AMINE
• 3-Bromo-5-ethoxypyridine
• 7-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
• 7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
• 2-amino-5-bromopyridin-3-ol