Amodiaquin dihydrochloride dihydrate Chemical Properties

RTECS 

GO7300100

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble in DMSO or methanol

color 

White to Yellow to Orange

λmax

342nm(MeOH)(lit.)

Merck 

14,572

Stability:

Hygroscopic

CAS DataBase Reference

6398-98-7(CAS DataBase Reference)

Safety Information

WGK Germany 

3

HS Code 

2933492250

MSDS

• Language:English Provider:SigmaAldrich

Amodiaquin dihydrochloride dihydrate Usage And Synthesis

Chemical Properties

Light yellow powder

Uses

An anti-malarial quinoline derivative that acts as an histamine N-methyltransferase inhibitor

Uses

antimalarial

brand name

Camoquin (Parke-Davis).

Biological Activity

Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.

in vivo

In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation.

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