Amodiaquin dihydrochloride dihydrate Chemical Properties

RTECS 

GO7300100

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble in DMSO or methanol

form 

Solid

color 

White to Yellow to Orange

λmax

342nm(MeOH)(lit.)

Merck 

14,572

Stability:

Hygroscopic

InChI

InChI=1S/C20H22ClN3O.ClH.H2O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19;;/h5-12,25H,3-4,13H2,1-2H3,(H,22,23);1H;1H2

InChIKey

AOFIMJMWPZOPAJ-UHFFFAOYSA-N

SMILES

N(C1C=CC(O)=C(CN(CC)CC)C=1)C1=CC=NC2=CC(Cl)=CC=C12.Cl.O

CAS DataBase Reference

6398-98-7(CAS DataBase Reference)

Safety Information

WGK Germany 

3

HS Code 

2933492250

MSDS

• Language:English Provider:SigmaAldrich

Amodiaquin dihydrochloride dihydrate Usage And Synthesis

Chemical Properties

Light yellow powder

Uses

antimalarial

Uses

An anti-malarial quinoline derivative that acts as an histamine N-methyltransferase inhibitor

brand name

Camoquin (Parke-Davis).

Biological Activity

Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.

in vivo

In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation.

IC 50

Plasmodium; Nurr1/NR4A2

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