3-azabicyclo[3.1.0]hexane Usage And Synthesis

Uses

3-Azabicyclo[3.1.0]hexane is a key structural feature found in a wide range of biologically active natural products, drugs, and agrochemicals.

Synthesis

3-azabicyclo[3.1.0]hexane synthesis: 1-Chlorocyclopropyl p-tolyl sulfoxides with an N,N-disubstituted aminomethyl group on the cyclopropane ring were prepared from dichloromethyl p-tolyl sulfoxide, α,β-unsaturated carboxylic acid esters, primary amines, and alkyl halides. Treatment of the sulfoxides with i-PrMgCl generated cyclopropylmagnesium carbenoids, which were inserted into an intramolecular C–H bond adjacent to a nitrogen atom to give 3-azabicyclo[3.1.0]hexane in yields of up to 94%.

3-azabicyclo[3.1.0]hexane(285-59-6)Related Product Information

• Procymidone
• TROVAFLOXACIN
• Alatrofloxacin
• 3-AZABICYCLO[3.1.0]HEXANE-2,4-DIONE
• ETHYL 2,4-DIOXO-3-[3-(TRIFLUOROMETHYL)PHENYL]-3-AZABICYCLO[3.1.0]HEXANE-6-CARBOXYLATE
• Duocarmycin A
• ADOZELESIN
• BICIFADINE
• 3-BENZYL-3-AZABICYCLO[3.1.0]HEXANE-2,4-DIONE
• Ciproximide
• 3-(3,5-difluorophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione
• AKOS 90874
• 3-(4-pyridinylmethyl)-3-azabicyclo[3.1.0]hexane-2,4-dione
• indolizomycin
• 3-[2-(4-fluorophenyl)-2-oxoethyl]-3-azabicyclo[3.1.0]hexane-2,4-dione
• TROVAFLOXACIN MESILATE
• ETHYL 2,4-DIOXO-3-PHENYL-3-AZABICYCLO[3.1.0]HEXANE-6-CARBOXYLATE
• 1H-Indole-2-carboxamide, N-(2-((4,5,8,8a-tetrahydro-7-methyl-4-oxocycl opropa(C)pyrrolo(3,2-e)indol-2(1H)-yl)carbonyl)-1H-indol-5-yl)-, (+-)-