IMIDAZO[1,2-A]PYRIDINE, 7-BROMO- Chemical Properties

Melting point:

118-120℃

Density 

1.69

storage temp. 

Sealed in dry,Room Temperature

form 

solid

pka

5.15±0.50(Predicted)

color 

White to off-white

InChI

InChI=1S/C7H5BrN2/c8-6-1-3-10-4-2-9-7(10)5-6/h1-5H

InChIKey

OASOJRLJBDCVNU-UHFFFAOYSA-N

SMILES

C12=NC=CN1C=CC(Br)=C2

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

HS Code 

2933599590

IMIDAZO[1,2-A]PYRIDINE, 7-BROMO- Usage And Synthesis

Synthesis

2-Amino-4-bromopyridine (5.0 g) and 2-chloroacetaldehyde (40% aqueous, 12 mL, 2.5 eq.) were dissolved in anhydrous ethanol (50 mL) and sodium bicarbonate (4.89 g, 2.0 eq.) was added. The reaction mixture was heated to reflux for 6 hours. Upon completion of the reaction, the organic solvent was removed by vacuum rotary evaporation. The residue was extracted with ethyl acetate (60 mL) and washed sequentially with water and saturated saline. The organic layer was dried with anhydrous sodium sulfate, filtered and purified by silica gel column chromatography to afford 7-bromoimidazo[1,2-a]pyridine (4.38 g, 78% yield) as a brown solid.

References

[1] Patent: CN106496222, 2017, A. Location in patent: Paragraph 0095; 0097
[2] Patent: WO2008/124323, 2008, A1. Location in patent: Page/Page column 68
[3] Patent: WO2008/121687, 2008, A2. Location in patent: Page/Page column 53
[4] Patent: WO2017/144633, 2017, A1. Location in patent: Page/Page column 101; 102
[5] Patent: WO2017/144639, 2017, A1. Location in patent: Page/Page column 87

IMIDAZO[1,2-A]PYRIDINE, 7-BROMO-(808744-34-5)Related Product Information

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