BZ-TYR-4-ABZ-OH
BZ-TYR-4-ABZ-OH Basic information
- Product Name:
- BZ-TYR-4-ABZ-OH
- Synonyms:
-
- BZ-TYR-4-ABZ-OH
- BENTIROMIDE
- btpaba
- chymex
- e-2663
- n-benzoyl-l-tyrosyl-p-aminobenzoicacid
- p-((n-benzoyl-l-tyrosin)amido)benzoicacid
- 4-(N-Benzoyl-L-tyrosyl)aminobenzoic acid
- CAS:
- 37106-97-1
- MF:
- C23H20N2O5
- MW:
- 404.42
- EINECS:
- 253-349-8
- Mol File:
- 37106-97-1.mol
BZ-TYR-4-ABZ-OH Chemical Properties
- Melting point:
- 240-242°
- alpha
- D25 +72.3° (c = 1 in DMF) (US 3801562); D25 +87° (c = 1 in DMF) (De Benneville)
- Boiling point:
- 526.04°C (rough estimate)
- Density
- 1.3093 (rough estimate)
- refractive index
- 1.6300 (estimate)
- storage temp.
- Store at RT.
- solubility
- DMSO:250.0(Max Conc. mg/mL);618.17(Max Conc. mM)
- form
- Solid
- pka
- 4.27±0.10(Predicted)
- color
- White to off-white
BZ-TYR-4-ABZ-OH Usage And Synthesis
Originator
PFD Oral Sol,Eisai,Japan,1980
Uses
Diagnostic aid (pancreas function determination).
Definition
ChEBI: The dipeptide obtained by condensation of N-benzoyl-L-tyrosine with 4-aminobenzoic acid. Used as a noninvasive screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic t erapy, it is given by mouth: the amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas.
Manufacturing Process
A mixture was made of L-tyrosine (18.1 g, 0.1 mol) benzoyl chloride (7.0 g,
0.05 mol) and 200 ml anhydrous THF. After stirring at reflux for 2 hours, the
mixture was cooled to room temperature, and the precipitate of tyrosine
hydrochloride filtered off (11 g, 46 meq. Cl-). The THF was evaporated and
the residue extracted with CCl4 (3 X 100 ml at reflux, discarded) and then
dissolved in ethyl acetate (200 ml) filtering off insolubles. The ethyl acetate
solution was evaporated to yield 132 g solid product, MP 159°-162°C (93%).
The tyrosine was recovered (8 g) by neutralization with aqueous alkali, from
the hydrochloride.
A solution was made of N-benzyl-L-tyrosine (5.7 g, 20 mmols) and Nmethylmorpholine (2.04 g, 20 mmols) in 60 ml of THF, at -15°C, and to it was
added ethyl chloroformate (2.08 g, 20 mmols). After 12 minutes, paminobenzoic acid (2.74 g, 20 mmols) dissolved in 25 ml of THF and 0.38 g of
p-toluenesulfonic acid (2 mmols) were added, and the temperature allowed to
rise to 5°C. After 2 hours and forty minutes, the mixture was poured into l
liter of 0.1 N cold HCl, stirred one-half hour, filtered and dried, to give 8,7 g,
MP 192°-223°C. The product was recrystallized from 90 ml methanol and 40
ml water, to give 6 g (74%) of product, N-benzoyl-L-tyrosyl-p-aminobenzoic acid, MP 240°-242°C.
brand name
Chymex (Savage).
Therapeutic Function
Diagnostic aid (pancreatic function)
BZ-TYR-4-ABZ-OHSupplier
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com
- Tel
- 17705183659
- sales@njleonbiotech.com
- Tel
- 025-025-58361106-805-805 13082558573
- liugang@njpeptide.com
BZ-TYR-4-ABZ-OH(37106-97-1)Related Product Information
- PANCREATIC POLYPEPTIDE (RANA TEMPORARIA)
- Secretin (human)
- CHEMBRDG-BB 9071855
- BZ-PHE-NH2
- 4-(BUTYLAMINO)BENZOIC ACID
- AC-TYR-NHME
- BZ-TYR-4-ABZ-OH
- 4-Acetamidobenzaldehyde
- BZ-TYR-NH2
- BZ-TYR-4-ABZ-OH SODIUM SALT,BZ-TYR-4-ABZ-OH NA SALT,BENTIROMIDE,bentiromide sodium,Bentiromide, N-Benzoyl-L-tyrosyl-4-aminobenzoic acid sodium salt
- p-Acetylamino benzoic acid
- 4-(propionylamino)benzoic acid
- AC-TYR-NH2