2-METHOXYBENZENETHIOL Chemical Properties

Melting point:

306.7-313.7 °C (decomp)

Boiling point:

99 °C/8 mmHg (lit.)

Density 

1.152 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.591(lit.)

FEMA 

4159 | 2-MERCAPTOANISOLE

Flash point:

204 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

H2O: insoluble

pka

6.62±0.43(Predicted)

form 

Liquid

Specific Gravity

1.152

color 

Clear yellow

Odor

at 1.00 % in propylene glycol. meaty smoked sausage powdery sweet spicy phenolic sulfurous

Odor Type

meaty

Sensitive 

Stench

JECFA Number

1666

BRN 

2042178

Stability:

Moisture Sensitive

LogP

204.00 °F. TCC

CAS DataBase Reference

7217-59-6(CAS DataBase Reference)

EPA Substance Registry System

Benzenethiol, 2-methoxy- (7217-59-6)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-36/37-37/39

RIDADR 

3334

WGK Germany 

3

RTECS 

DC1790000

F 

10-13-23

Hazard Note 

Harmful/Stench

TSCA 

T

HazardClass 

IRRITANT, STENCH

HS Code 

29309090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-METHOXYBENZENETHIOL Usage And Synthesis

Chemical Properties

clear yellow liquid

Chemical Properties

Colorless to yellowish liquid; pungent, onion aroma.

Occurrence

Reported found in coffee.

Uses

2-Methoxythiophenol is used in the synthesis of berberine-thiophenyl hybrids as multifunctional agents. Inhibition of acetylcholinesterase, butyrylcholinesterase and AB aggregation antioxidant activity.

Uses

2-Methoxythiophenol was used in the synthesis of:

• (4S)-N-[(2S)-2-methy-3-(2-methoxyphenylthio)propanoyl]-4-phenyloxazolidin-2-one
• 2-(4-fluorophenyl)-6-(2-methoxyphenylsulfanyl)imidazo[1,2-a]pyridine
• 2-(2-methoxyphenylsulfanyl)benzoic acid

Definition

ChEBI: 2-Methoxybenzenethiol is a thiol.

Aroma threshold values

Meaty type, very high strength odor, recommend smelling in a 0.10% solution or less.

Taste threshold values

Meaty sausage taste at 1 ppm in water.

General Description

2-Methoxythiophenol is a sulfur-containing compound that can be used as a flavoring agent.

Synthesis

2-Methoxybenzenethiol is prepared：
1) from or(ho-Aminophenol-methylether via Diazoreaction.
2) from Sodium phenoxide plus Sulfur at 200° C. to yield 2: 2'-Dihydroxy-diphenyldisulfide. Reduction and Methylation afford the title ether.

2-METHOXYBENZENETHIOL(7217-59-6)Related Product Information

• 3-(CHLOROSULFONYL)-4-METHOXYBENZOIC ACID
• 2-METHOXYBENZENETHIOL
• 5-BROMO-2-METHOXYBENZENESULFONYL CHLORIDE
• Tioxolone
• PHENOXATHIIN
• 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
• 2,5-DIMETHOXYBENZENESULFONYL CHLORIDE
• 2-(Trifluoromethoxy)benzene-1-sulfonyl chloride
• 2-(TRIFLUOROMETHOXY)THIOPHENOL
• 4-Amino-2,5-dimethoxy-N-phenylbenzenesulphonamide
• p-Anisidine-2-sulfonic acid
• 1,3-Dimethoxy-2-(methylthio)benzene
• 4-BROMO-2-(TRIFLUOROMETHOXY)THIOPHENOL
• 4-(TRIFLUOROMETHOXY)THIOPHENOL
• 4-METHOXYBENZENETHIOL,P-METHOXYBENZENETHIOL,para-Methoxybenzenethiol,4-Mercaptoanisole, 4-Methoxybenzenethiol
• 3-(TRIFLUOROMETHOXY)THIOPHENOL
• M-METHOXYBENZENETHIOL,3-METHOXYBENZENETHIOL,3-Mercaptoanisole~3-Methoxybenzenethiol,Methoxybenzenethiol,meta-Methoxybenzenethiol
• 3,4-DIMETHOXYTHIOPHENOL