5-Bromofuroic acid Chemical Properties

Melting point:

188-190 °C(lit.)

Boiling point:

281.6±25.0 °C(Predicted)

Density 

1.7703 (rough estimate)

refractive index 

1.4690 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

2.84±0.10(Predicted)

form 

Crystalline Flakes or Powder

color 

White to cream or beige

BRN 

118354

InChIKey

YVTQHZDUDUCGRD-UHFFFAOYSA-N

CAS DataBase Reference

585-70-6(CAS DataBase Reference)

NIST Chemistry Reference

5-Bromofuroic acid(585-70-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

24/25-39-26

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29321900

MSDS

• Language:English Provider:5-Bromo-2-furancarboxylic acid
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

5-Bromofuroic acid Usage And Synthesis

Chemical Properties

white to cream or beige crystalline flakes

Synthesis

Furan-2-carboxylic acid (2.50 g, 22.3 mmol) was used as starting material and dissolved in a solvent mixture of glacial acetic acid (2.0 ml) and carbon tetrachloride (20.0 ml). Bromine (0.8 ml, 13.3 mmol) was added slowly in three portions at 20°C, 6 hours apart, and the reaction was carried out for 5 minutes after addition. The reaction temperature was then maintained at 60°C with continuous stirring for 24 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. The resulting solid was washed with hot deionized water, filtered and dried to afford 5-bromo-2-furoic acid (3.46 g, 18.1 mmol) in 86% yield.

References

[1] Patent: CN106977476, 2017, A. Location in patent: Paragraph 0073-0093
[2] Journal of Materials Chemistry A, 2014, vol. 2, # 18, p. 6589 - 6597
[3] Journal of Pharmaceutical Sciences, 1981, vol. 70, # 10, p. 1095 - 1100
[4] Heterocycles, 1994, vol. 38, # 4, p. 759 - 768
[5] Justus Liebigs Annalen der Chemie, 1953, vol. 580, p. 169,187

5-Bromofuroic acid(585-70-6)Related Product Information

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• 2,5-Furandicarboxylic acid
• 3-Furoic acid
• Furazolidone
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• 5-Bromo-1-benzofuran
• Mometasone furoate
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• Retinoic acid
• 2-Furoic acid
• 4-Bromomethylbenzoic acid
• Methyl 2-bromobenzoate
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