2,3-Difluorophenol Chemical Properties

Melting point:

39-42 °C (lit.)

Boiling point:

54 °C/25 mmHg (lit.)

Density 

1.2483 (estimate)

Flash point:

134 °F

storage temp. 

Inert atmosphere,2-8°C

pka

7.71±0.10(Predicted)

form 

powder to lump to clear liquid

color 

White or Colorless to Almost white or Almost colorless

BRN 

2082265

InChI

InChI=1S/C6H4F2O/c7-4-2-1-3-5(9)6(4)8/h1-3,9H

InChIKey

RPEPGIOVXBBUMJ-UHFFFAOYSA-N

SMILES

C1(O)=CC=CC(F)=C1F

CAS DataBase Reference

6418-38-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

F,Xn,Xi,C

Risk Statements 

11-22-36/37/38-34-20/21/22

Safety Statements 

26-45-36/37/39-16

RIDADR 

UN 1325 4.1/PG 2

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

4.1

PackingGroup 

III

HS Code 

29081000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,3-Difluorophenol Usage And Synthesis

Chemical Properties

white crystalline low melting mass

Uses

Intermediates of Liquid Crystals

Application

2,3-Difluorophenol was used in the synthesis of material-poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} (PMDFPS) sensitive to toxic organophosphate.

Synthesis

Step 1: In a 500 mL round-bottomed flask, dissolve 2,3-difluorophenylboronic acid (30 g, 189.98 mmol, 1.00 eq.) in dichloromethane (250 mL). Hydrogen peroxide (30 mL) was added slowly and dropwise under stirring conditions. The reaction mixture was stirred continuously at 25°C for 2 hours. Upon completion of the reaction, the reaction mixture was washed sequentially with water and saturated saline, the organic phase was dried over anhydrous magnesium sulfate, and subsequently concentrated under reduced pressure to afford 2,3-difluorophenol 23 g (93% yield) as a brown oil.

References

[1] K.P. RAJAPPAN NAIR . Supersonic jet microwave rotational spectrum of 2,3-difluorophenol[J]. Journal of Molecular Structure, 2019, 1195: Pages 479-484. DOI:10.1016/j.molstruc.2019.06.004.
[2] WEI HE . Analytical application of poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} as a QCM coating for DMMP detection[J]. Talanta, 2008, 76 3: Pages 698-702. DOI:10.1016/j.talanta.2008.04.022.
[3] E. MARZI M. S J Gorecka. The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates[J]. Synthesis-Stuttgart, 2004, 441 1: 1609-1618. DOI:10.1055/S-2004-829110.

2,3-Difluorophenol (6418-38-8)Related Product Information

• 4-Fluorophenol
• Xylenol
• 1,3-Difluorobenzene
• 2-Phenylphenol
• 4-Trifluoromethylphenol
• 3,4-DIFLUOROPHENOL
• 3,5-DIFLUOROPHENOL
• 2,6-DIFLUOROPHENOL
• 6-NITRO-2,3-DIFLUOROPHENOL
• PENTAFLUOROPHENYL ACRYLATE
• PENTAFLUOROPHENOXYACETIC ACID
• Pentafluorophenol
• 2,3,4-TRIFLUOROPHENOL
• FMOC-ASP(OTBU)-OPFP
• 2,3,5,6-TETRAFLUOROANISOLE
• PENTAFLUOROPHENYL METHACRYLATE
• 2,3,4-Trifluoroanisole
• 2,5-DINITROPHENOL