3,3-Diphenylpropionic acid CAS#: 606-83-7

3,3-Diphenylpropionic acid Basic information

Product Name:

3,3-Diphenylpropionic acid

Synonyms:

3,3-diphenylpropanoate
3,3-Dipenylpropionicacid
3,3-Diphenylpropanoic acid
3,3-Diphenylpropanoicacid
Benzhydrylaceticacid
beta-Phenylbenzenepropanoic acid
beta-phenyl-benzenepropanoicaci
Diphenylpropionic acid

CAS:

606-83-7

MF:

C15H14O2

MW:

226.27

EINECS:

210-125-4

Product Categories:

Building Blocks
C13 to C42+
Carbonyl Compounds
Carboxylic Acids
Chemical Synthesis
Organic Building Blocks
Organic acids
C13 to C42+
Carbonyl Compounds
Carboxylic Acids

Mol File:

606-83-7.mol

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3,3-Diphenylpropionic acid Chemical Properties

Melting point:: 151-154 °C (lit.)
Boiling point:: 327.88°C (rough estimate)
Density: 1.0891 (rough estimate)
refractive index: 1.6530 (estimate)
Flash point:: 113 °C
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 4.45±0.10(Predicted)
form: Crystalline Powder
color: White to light yellow
Water Solubility: slightly soluble
BRN: 1912506
InChIKey: BZQGAPWJKAYCHR-UHFFFAOYSA-N
CAS DataBase Reference: 606-83-7(CAS DataBase Reference)
NIST Chemistry Reference: Benzenepropanoic acid, «beta»-phenyl-(606-83-7)
EPA Substance Registry System: 3,3-Diphenylpropionic acid (606-83-7)

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Safety Information

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-37/39-26
WGK Germany: 3
HS Code: 29163990

MSDS

Language:English Provider:3,3-Diphenylpropionic acid
Language:English Provider:ACROS
Language:English Provider:SigmaAldrich

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3,3-Diphenylpropionic acid Usage And Synthesis

Chemical Properties

WHITE TO LIGHT YELLOW CRYSTALLINE POWDER

Uses

3,3-Diphenylpropionic Acid is used in the preparation of steroid 5α-reductase inhibiting acylpiperidines. It can also be used in the preparation of calpain-inhibitory piptidyl α-ketoacids and esters.

Synthesis Reference(s)

Journal of the American Chemical Society, 91, p. 7510, 1969 DOI: 10.1021/ja01054a049
The Journal of Organic Chemistry, 39, p. 623, 1974 DOI: 10.1021/jo00919a009
Tetrahedron Letters, 35, p. 1539, 1994 DOI: 10.1016/S0040-4039(00)76752-9

Purification Methods

Crystallise the acid from EtOH. [Beilstein 9 H 680.]

3,3-Diphenylpropionic acid Preparation Products And Raw materials

Preparation Products

1-BROMO-3,3-DIPHENYLPROPANE 3,3-Diphenylpropanol 3,3-Diphenylpropionic Acid Ethyl Ester

Raw materials

Aluminium chloride hexahydrate

3,3-Diphenylpropionic acidSupplier

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