3-Aminopyridine Chemical Properties

Melting point:

60-63 °C(lit.)

Boiling point:

248 °C(lit.)

Density 

1.0308 (estimate)

refractive index 

1.5560 (estimate)

Flash point:

124 °C

storage temp. 

Poison room

solubility 

>1000g/l

pka

6.04(at 25℃)

form 

Liquid

color 

Clear colorless to yellow

PH

10 (100g/l, H2O, 20℃)

Water Solubility 

It is soluble in water as well as soluble in alcohol, benzene.

Sensitive 

Air Sensitive & Hygroscopic

Merck 

14,473

BRN 

105692

InChIKey

CUYKNJBYIJFRCU-UHFFFAOYSA-N

CAS DataBase Reference

462-08-8(CAS DataBase Reference)

NIST Chemistry Reference

3-Pyridinamine(462-08-8)

EPA Substance Registry System

3-Aminopyridine (462-08-8)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

23/24/25-33-36/37/38-25

Safety Statements 

36/37/39-45-37/39-28B-26

RIDADR 

UN 2671 6.1/PG 2

WGK Germany 

3

RTECS 

US1650000

F 

3-8-9-23

Hazard Note 

Toxic/Irritant

TSCA 

T

HazardClass 

6.1

PackingGroup 

II

HS Code 

29333999

Toxicity

LD50 ipr-mus: 28 mg/kg JMCMAR 8,296,65

MSDS

• Language:English Provider:3-Pyridinamine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-Aminopyridine Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

3-Aminopyridine is a monosubstituted pyridine that shows convulsive effects on cortical Neurons. 3-Aminopyridine is used in the synthesis of of organic ligand 3-Pyridylnicotinamide. 3-Aminopyridine al ong with other aminopyridines have been shown to reversibly block voltage-dependent potassium channels,

Uses

manufacture of pharmaceuticals and dyes.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 4, p. 45, 1963
The Journal of Organic Chemistry, 57, p. 5254, 1992
Tetrahedron Letters, 39, p. 1313, 1998 DOI: 10.1016/S0040-4039(97)10877-2

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx,.

Purification Methods

It crystallises from *benzene, CHCl3/pet ether (b 60-70o), or *benzene/pet ether (4:1). [Beilstein 22/9 V 3.]

3-Aminopyridine(462-08-8)Related Product Information

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• 3,4-Diaminopyridine
• 2-CHLORO-3-NITROPYRIDINE
• 2-Amino-5-nitropyridine
• 2-(2-AMINOETHYLAMINO)-5-NITROPYRIDINE
• 2-Methoxy-5-nitropyridine
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• 5-Amino-2-chloropyridine
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• 3-Amino-2-pyridinecarboxylic acid
• 3-Amino-2-Chloropyridine 2-Chloro-3-Aminopyridine
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