3-Aminopyridine Chemical Properties

Melting point:

60-63 °C(lit.)

Boiling point:

248 °C(lit.)

Density 

1.0308 (estimate)

refractive index 

1.5560 (estimate)

Flash point:

124 °C

storage temp. 

Poison room

solubility 

>1000g/l

pka

6.04(at 25℃)

form 

Liquid

color 

Clear colorless to yellow

PH

10 (100g/l, H2O, 20℃)

Water Solubility 

It is soluble in water as well as soluble in alcohol, benzene.

Sensitive 

Air Sensitive & Hygroscopic

Merck 

14,473

BRN 

105692

InChIKey

CUYKNJBYIJFRCU-UHFFFAOYSA-N

CAS DataBase Reference

462-08-8(CAS DataBase Reference)

NIST Chemistry Reference

3-Pyridinamine(462-08-8)

EPA Substance Registry System

3-Aminopyridine (462-08-8)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

23/24/25-33-36/37/38-25

Safety Statements 

36/37/39-45-37/39-28B-26

RIDADR 

UN 2671 6.1/PG 2

WGK Germany 

3

RTECS 

US1650000

F 

3-8-9-23

Hazard Note 

Toxic/Irritant

TSCA 

T

HazardClass 

6.1

PackingGroup 

II

HS Code 

29333999

Toxicity

LD50 ipr-mus: 28 mg/kg JMCMAR 8,296,65

MSDS

• Language:English Provider:3-Pyridinamine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-Aminopyridine Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

3-Aminopyridine is a monosubstituted pyridine that shows convulsive effects on cortical Neurons. 3-Aminopyridine is used in the synthesis of of organic ligand 3-Pyridylnicotinamide. 3-Aminopyridine al ong with other aminopyridines have been shown to reversibly block voltage-dependent potassium channels,

Uses

manufacture of pharmaceuticals and dyes.

Uses

3-Aminopyrodine is also used as an intermediate for agrochemicals, pharmaceuticals and colorants. These are involved in photosensitizer chemistry, luminescent materials, metal complex chemistry and liquid crystal. Aminopyridine is used as a monomer for polymerization. It is also used in the Production of cationic dyes and Apa amoxicillin sodium raw materials.

Synthesis Reference(s)

Tetrahedron Letters, 39, p. 1313, 1998 DOI: 10.1016/S0040-4039(97)10877-2
The Journal of Organic Chemistry, 57, p. 5254, 1992 DOI: 10.1021/jo00045a047

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx,.

Purification Methods

It crystallises from *benzene, CHCl3/pet ether (b 60-70o), or *benzene/pet ether (4:1). [Beilstein 22/9 V 3.]

3-Aminopyridine(462-08-8)Related Product Information

• (3alpha)-3-chloro-Cholest-4-ene
• 1H-Imidazole-1-ethanol, alpha-(4-bromo-2,3,5,6-tetramethylphenyl)-
• 2-CHLORO-3,5-DINITROPYRIDINE
• 3,4-Diaminopyridine
• 2-CHLORO-3-NITROPYRIDINE
• 2-Amino-5-nitropyridine
• 2-(2-AMINOETHYLAMINO)-5-NITROPYRIDINE
• 2-Methoxy-5-nitropyridine
• 2-methoxy-5-aminopyridine
• 5-Amino-2-chloropyridine
• 3-Aminopyridine
• 3-Amino-2-bromopyridine
• 3-Amino-2-pyridinecarboxylic acid
• 3-Amino-2-Chloropyridine 2-Chloro-3-Aminopyridine
• Acetaminophen
• 4-Dimethylaminopyridine
• 4-Aminopyridine;4-AP; Pyridin-4-amine,4-Aminopyridine (RTC is agent for this item in Europe)
• 2-Aminopyridine