Basic information Safety Supplier Related

METHIOTHEPIN MALEATE

Basic information Safety Supplier Related

METHIOTHEPIN MALEATE Basic information

Product Name:
METHIOTHEPIN MALEATE
Synonyms:
  • 1-[10,11-Dihydro-8-(methylthio)dibenzo(Z)[b,f]thiepin-10-yl]-4-methylpiperazinemaleate
  • (+-)-1-(10,11-dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiper
  • (+-)-10-(4-methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepi
  • (+-)-8-methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin
  • dibenzo(b,f)thiepin,10,11-dihydro-10-(4-methylpiperazinyl)-8-(methylthio)-(
  • methiothepin
  • 8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepine
  • Methiothepine
CAS:
20229-30-5
MF:
C20H24N2S2
MW:
356.55
Product Categories:
  • Serotonin receptor
Mol File:
20229-30-5.mol
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METHIOTHEPIN MALEATE Chemical Properties

Melting point:
88-89°
Boiling point:
462.9±45.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
H2O: 13 mg/mL
form 
solid
pka
7.95±0.42(Predicted)
color 
white
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Safety Information

WGK Germany 
3

MSDS

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METHIOTHEPIN MALEATE Usage And Synthesis

Uses

5HT1&2 receptor antagonist

Uses

Methiothepin Maleate exhibits anticonvulsant property and it is able to suppress pentylenetetrazol induced fos expression in zebrafish. In addition, Methiothepin Maleate is a 5-HT antagonist.

Definition

ChEBI: Methiothepin is a dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively). It has a role as an antipsychotic agent, a dopaminergic antagonist, a serotonergic antagonist and a geroprotector. It is a N-alkylpiperazine, a dibenzothiepine, an aryl sulfide and a tertiary amino compound. It is a conjugate base of a methiothepin(2+).

Biological Activity

Potent 5-HT 2 antagonist, also active as 5-HT 1 antagonist. Differentiates 5-HT 1D sub-types. Also displays affinity for rodent 5-HT 5B , 5-HT 5A , 5-HT 7 and 5-HT 6 receptors (pK 1 values are 6.6, 7.0, 8.4 and 8.7 respectively).

METHIOTHEPIN MALEATESupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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3bsc@sina.com
Shanghai TaoSu Biochemical Technology Co., Ltd.
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021-33632979
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info@tsbiochem.com
Shanghai Synchem Pharma Co., ltd
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21-619849051-1 18521059765
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synchempharma@aliyun.com
EMMX Biotechnology LLC
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888-539-0666
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info@emmx.com
TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com