METHIOTHEPIN MALEATE
METHIOTHEPIN MALEATE Basic information
- Product Name:
- METHIOTHEPIN MALEATE
- Synonyms:
-
- 1-[10,11-Dihydro-8-(methylthio)dibenzo(Z)[b,f]thiepin-10-yl]-4-methylpiperazinemaleate
- (+-)-1-(10,11-dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiper
- (+-)-10-(4-methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepi
- (+-)-8-methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin
- dibenzo(b,f)thiepin,10,11-dihydro-10-(4-methylpiperazinyl)-8-(methylthio)-(
- methiothepin
- 8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepine
- Methiothepine
- CAS:
- 20229-30-5
- MF:
- C20H24N2S2
- MW:
- 356.55
- Product Categories:
-
- Serotonin receptor
- Mol File:
- 20229-30-5.mol
METHIOTHEPIN MALEATE Chemical Properties
- Melting point:
- 88-89°
- Boiling point:
- 462.9±45.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- H2O: 13 mg/mL
- form
- solid
- pka
- 7.95±0.42(Predicted)
- color
- white
MSDS
- Language:English Provider:SigmaAldrich
METHIOTHEPIN MALEATE Usage And Synthesis
Uses
5HT1&2 receptor antagonist
Uses
Methiothepin Maleate exhibits anticonvulsant property and it is able to suppress pentylenetetrazol induced fos expression in zebrafish. In addition, Methiothepin Maleate is a 5-HT antagonist.
Definition
ChEBI: Methiothepin is a dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively). It has a role as an antipsychotic agent, a dopaminergic antagonist, a serotonergic antagonist and a geroprotector. It is a N-alkylpiperazine, a dibenzothiepine, an aryl sulfide and a tertiary amino compound. It is a conjugate base of a methiothepin(2+).
Biological Activity
Potent 5-HT 2 antagonist, also active as 5-HT 1 antagonist. Differentiates 5-HT 1D sub-types. Also displays affinity for rodent 5-HT 5B , 5-HT 5A , 5-HT 7 and 5-HT 6 receptors (pK 1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
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METHIOTHEPIN MALEATE(20229-30-5)Related Product Information
- Oxyprothepin 5,8-disulfide
- Oxyprothepin
- METHIOTHEPIN MALEATE
- 1-Piperazineethanol, 4-(10,11-dihydro-8-(methylthio)dibenzo(b,f)thiepi n-10-yl)-alpha-ethyl-, monomethanesulfonate
- 1-Piperazinepropanol, 4-(10,11-dihydro-8-(methylsulfonyl)dibenzo(b,f)t hiepin-10-yl)-, 1-oxide
- 1-(10,11-Dihydro-8-(methylsulfonyl)dibenzo(b,f)thiepin-10-yl)-4-methyl piperazine
- METHIOTHEPIN MALEATE