15(S)-15-METHYL PROSTAGLANDIN E1
15(S)-15-METHYL PROSTAGLANDIN E1 Basic information
- Product Name:
- 15(S)-15-METHYL PROSTAGLANDIN E1
- Synonyms:
-
- 15(S)-15-METHYL PROSTAGLANDIN E1
- 9-OXO-11ALPHA,15S-DIHYDROXY-15-METHYL-PROST-13E-EN-1-OIC ACID
- 15(S)-15-methyl Prostaglandin E1
- OMNFCPCBKCERJP-XBZFKEOQSA-N
- 15(S)-15-methyl PGE1
- 9-oxo-11α,15S-dihydroxy-15-methyl-prost-13E-en-1-oic acid
- Prost-13-en-1-oic acid,11,15-dihydroxy-15-methyl-9-oxo-, (11a,13E,15S)- (9CI)
- Prost-13-en-1-oic acid, 11,15-dihydroxy-15-methyl-9-oxo-, (11α,13E,15S)- (9CI)
- CAS:
- 35700-26-6
- MF:
- C21H36O5
- MW:
- 368.51
- Mol File:
- 35700-26-6.mol
15(S)-15-METHYL PROSTAGLANDIN E1 Chemical Properties
- Boiling point:
- 534.9±50.0 °C(Predicted)
- Density
- 1.118±0.06 g/cm3(Predicted)
- solubility
- DMF: >100 mg/ml (from PGE1); DMSO: >50 mg/ml (from PGE1); Ethanol: >50 mg/ml (from PGE1); PBS pH 7.2: >1.6 mg/ml (from PGE1)
- pka
- 4.77±0.10(Predicted)
15(S)-15-METHYL PROSTAGLANDIN E1 Usage And Synthesis
Description
15(S)-
Uses
15-Methylprostaglandin E1 (15S-15-Methyl-PGE1) exhibits a positiv chronotropic effect, increases the heart rate and levels of nicardipine[1].
Definition
ChEBI: 15-Methyl-15S-Prostaglandin E1 is a prostanoid.
in vivo
15-Methylprostaglandin E1 (0.01-100 nM) induces a long-lasting heart rate increases in a dose-dependent manner without alters in heart contractility in guinea pig, which is probably altered by Na+/Ca+ concentration.
| Animal Model: | guinea pigs with isolated atria[1] |
| Dosage: | 0.01-100 nM |
| Administration: | |
| Result: | Increased heart rate. |
References
1. Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R. Prostaglandins and human respiratory tract smooth muscle: Structure activity relationship Adv. Prostaglandin Thromboxane Res. 7,969-980(1980).
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