(+)-BORNEOL Chemical Properties

Melting point:

206-209 °C (lit.)

alpha 

36 º (C=5 IN ETOH)

Boiling point:

237.64°C (rough estimate)

Density 

0.8704 (rough estimate)

refractive index 

1.4723 (estimate)

FEMA 

2157 | BORNEOL

Flash point:

150 °F

storage temp. 

2-8°C

solubility 

DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 16 mg/ml; Ethanol: 16 mg/ml

pka

15.36±0.60(Predicted)

Odor

at 10.00 % in dipropylene glycol. pine camphor earthy

Odor Type

balsamic

optical activity

[α]20/D 37.0±2.0°, c = 5 in ethanol

Water Solubility 

0.74g/L(25 ºC)

BRN 

2038056

LogP

2.850

CAS DataBase Reference

464-43-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

F,Xn

Risk Statements 

11-20/21/22

Safety Statements 

16-33-36-7/9

RIDADR 

UN 1312 4.1/PG 3

WGK Germany 

3

RTECS 

ED7060000

HazardClass 

4.1

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich

(+)-BORNEOL Usage And Synthesis

Chemical Properties

Almost insoluble in water, poorly soluble in Propylene glycol, very soluble in alcohol, miscible with most perfume oils. Dry-camphoraceous, woody-peppery odor. The dryness is characteristic and constitutes the main difference from the odor of isoBorneol. The odor of Borneol is often compared to that of a good grade Rosemary oil (in which Borneol is present).

Uses

(+)-Borneol has been used to study its antiapoptotic, antioxidative and neuroprotective effect in human neuroblastoma cells (SH-SY5Y).

Application

(+)-Borneol has a woody, somewhat minty and slightly burning taste. This alcohol blends excellently with Olibanum products for “incense” type fragrances, and it forms a good background in many herbaceous-camphoraceous fragrances, Lavender- and Citrus cologne types, many tyDes of Room-freshener fragrance, Pine odors, etc.

Definition

ChEBI: (+)-borneol is a borneol. It is an enantiomer of a (-)-borneol.

General Description

(+)-Borneol, a bicyclic monoterpene, is found in the essential oils of medicinal plants and is commonly used in traditional Chinese medicine for analgesia and anaesthesia.

Anticancer Research

Wild asparagus root is known as “tian men dong” in traditional Chinese medicine. Itis used to relieve asthma, suppress coughing, and promote expectoration (Huang1998). It is held to be sweet and bitter in flavour and cold in nature, nourishing thelungs and moistening dryness (McNamara and Song 1995). Though studies conductedon asparagus root to examine its biological effects have only been conductedon animals, the evidence so far shows anticancer activity against leukaemia and lungcancer by means of the inhibition of tumour necrosis factor alpha (Huang et al. 2008).

Purification Methods

It can be steam distilled, the distillate is extracted into Et2O, the extract dried with Drierite and evaporated. The residue is then recrystallised from boiling EtOH (charcoal) or pet ether. [Clark & Read J Chem Soc 1773 1934, Beilstein 6 III 295, 6 IV 281.]

(+)-BORNEOL(464-43-7)Related Product Information

• N-Benzyl-2-norbornanamine
• Bornyl acetate
• Carbic anhydride
• 5-Norbornene-2-carboxamide
• N-Hydroxy-5-norbornene-2,3-dicarboximide
• L(-)-Borneol
• 2-Hydroxyethyl 5-norbornene-2-carboxylate
• 2-METHYLISOBORNEOL
• N,N-Diethyl-endo-2-aminonorbornane
• 5-VINYL-2-NORBORNENE
• DL-Isoborneol
• Borneol
• endo-2-Acetylbicyclo[2.2.1]hept-5-ene
• Isobornyl isobutyrate
• (R)-(+)-BORNYLAMINE
• ENDO-NORBORNEOL
• Isobornyl acrylate
• 5-Norbornene-2,3-dicarboxylic acid