(-)-LEUKOTRIENE A4 METHYL ESTER Chemical Properties

storage temp. 

−20°C

solubility 

Acetone: >50 mg/ml; DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: insoluble and unstable.

form 

triethylamine:hexane solution

Safety Information

Hazard Codes 

F,Xn,N

Risk Statements 

11-36/37/38-48/20-51/53-62-65-67

Safety Statements 

9-16-29-33-36/37-61-62

RIDADR 

UN 1208 3/PG 2

WGK Germany 

2

MSDS

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(-)-LEUKOTRIENE A4 METHYL ESTER Usage And Synthesis

Description

Leukotriene A₄ (LTA₄) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA₄ synthase activities. LTA₄ is rapidly metabolized by LTA₄ hydrolase or LTC₄ synthase to LTB₄ or LTC₄, respectively. LTA₄, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA₄ by 15-LO leads to lipoxin biosynthesis. LTA₄ as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.

Uses

LTA4 (Leukotriene A4 methyl ester) is an unstable intermediate in the biosynthesis of LTB4 and LTC4.

References

[1] T SHIMIZU  B S  O R?dmark. Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1984, 81 3: 689-693. DOI: 10.1073/pnas.81.3.689
[2] BENGT SAMUELSSON. Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects[J]. Science, 1987, 237 4819. DOI: 10.1126/science.2820055
[3] J A MACLOUF  R C M. Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4.[J]. The Journal of Biological Chemistry, 1988, 263 1: 174-181.

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