4-Chloro-N-methylpiperidine Chemical Properties

Melting point:

160-165°C

Boiling point:

162°C(lit.)

Density 

1.02

vapor pressure 

3.493hPa at 25℃

refractive index 

1.4670-1.4710

Flash point:

48 °C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Ethanol (Slightly) , Methanol (Slightly)

form 

clear liquid to slightly cloudy liquid

pka

7.88±0.10(Predicted)

color 

Colorless to Light yellow to Light orange

Water Solubility 

1.533g/L at 29℃

InChIKey

MYGXGCCFTPKWIH-UHFFFAOYSA-N

LogP

1.318 at 25℃

CAS DataBase Reference

5570-77-4(CAS DataBase Reference)

EPA Substance Registry System

Piperidine, 4-chloro-1-methyl- (5570-77-4)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

10-34-36/38

Safety Statements 

22-24/25-45-36/37/39-26-36-16

RIDADR 

1993

HazardClass 

3

PackingGroup 

III

HS Code 

29333990

4-Chloro-N-methylpiperidine Usage And Synthesis

Chemical Properties

Clear colorless liquid

Uses

4-Chloro-1-methylpiperidine is a reactant in the synthesis of indole and benzimidazole piperazines as histamine H4 receptor antagonist.

Flammability and Explosibility

Not classified

Physiological effects

4-Chloro-N-methylpiperidine can be used to treat bronchial asthma, chronic obstructive pulmonary disease, and other respiratory disorders by inhibiting the production of histamine in the body. It also has antihistaminic effects that may be due to its ability to inhibit histamine release from mast cells or block H1 receptors.

4-Chloro-N-methylpiperidine(5570-77-4)Related Product Information

• 4-Chloropiperidine
• Chloromethyltrimethylsilane
• Methyl N-methyl piperidine-4-carboxylate
• 1-Methyl-4-piperidinemethanol
• 1-Methyl-3-piperidinemethanol
• 1,2-Propyleneglycol diacetate
• Indole-4-carboxaldehyde
• 2-CHLORO-6-NITROANILINE
• Triacetonediamine
• tert-Butyldimethylsilyl chloride
• 2,2,6,6-Tetramethyl-4-piperidinol
• 2-Chloro-5-chloromethylpyridine
• Chloromethane
• CHLOROMETHYLPHENYLSILANE
• Ethyl 1-methyl-4-piperidinecarboxylate
• Ethyl 1-methylnipecotate
• 1-Methyl-4-piperidone
• Difluorochloromethane