Propyphenazone
Propyphenazone Basic information
- Product Name:
- Propyphenazone
- Synonyms:
-
- 1,2-Dihydro-4-isopropyl-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
- 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3h-pyrazol-3-on
- 3-Pyrazolin-5-one, 4-isopropyl-2,3-dimethyl-1-phenyl-
- 4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
- 4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on
- 4-Isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
- 4-Isopropyl-2,3-dimethyl-5-oxo-1-phenyl-3-pyrazoline
- 4-isopropyl-antipyrin
- CAS:
- 479-92-5
- MF:
- C14H18N2O
- MW:
- 230.31
- EINECS:
- 207-539-2
- Product Categories:
-
- Aromatics
- Heterocycles
- Active Pharmaceutical Ingredients
- API's
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 479-92-5.mol
Propyphenazone Chemical Properties
- Melting point:
- 102-105°C
- Boiling point:
- 372.3°C (rough estimate)
- Density
- 1.0371 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
- pka
- 1.46±0.65(Predicted)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 743.6g/L(25.35 ºC)
- Merck
- 14,7871
- BRN
- 204533
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 479-92-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Propyphenazone(479-92-5)
- EPA Substance Registry System
- 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl- (479-92-5)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- RTECS
- CD2800000
- HS Code
- 2933.39.9200
Propyphenazone Usage And Synthesis
Description
This uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known.
Chemical Properties
solid
Uses
Analgesic; antipyretic; anti-inflammatory.
Definition
ChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group.
brand name
539 grippe-dragees;Amipylo-n;Balpiren;Baukal;Caffalgina;Camoplex;Cantacin;Cerebrol;Daturmed;Degripol;Dentocaps a;Dim-antos;Dolibral;Dolo-mineuron;Dysmalgin;Ejcopyrin;Epizon;Escomen;Estesina;Fd 8;Febral;Finigripp;Grippocaps;Heaven;Infantex;Influvit;Isopronazon;Kavapyret;Kuronde;Lysadestat;Mamaslu;Milneuron;Myo-europan;Neuramin;Neuridal;Neuro-spondryl;Nodiras;Noric;Otobacid;Pfeil;Reomin;Retamex;Rheumanol;Rhinivict;Sanalgin-p;Saridon neu;Saridone;Sedospin;Servalgin;Sonotryl;Spalt;Spongamed;Stona;Synpyrin;Vivcet;Wauco-sin;Wecontrin.
World Health Organization (WHO)
Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations. See also WHO comment for aminophenazone.
Clinical Use
Propyphenazone is a derivative of phenazone and has a similar analgesic and antipyretic action. It is used as a monocompound as well as in multi-ingredient preparations.
References
Hartsen., J. Chem. Soc., 511 (1873) Mirande., Compt. rend., 168,316 (1919)
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Propyphenazone(479-92-5)Related Product Information
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- Dimethyl sulfoxide
- ETHANE
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- Dimethyl ether
- Chlorodimethylphenylsilane
- DIANTIPYRYLMETHANE
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- Pralmorelin
- Dimethyl carbonate
- Diisopropyl ether
- Isoproterenol
- Diphenolic acid
- N,N-Dimethylformamide
- N,N-Dimethylaniline
- Dimethyl sulfide
- Isoproturon
- Dimethyl sulfone