Propyphenazone Chemical Properties

Melting point:

102-105°C

Boiling point:

372.3°C (rough estimate)

Density 

1.0371 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.

pka

1.46±0.65(Predicted)

color 

White to Off-White

Water Solubility 

743.6g/L(25.35 ºC)

Merck 

14,7871

BRN 

204533

Stability:

Stable. Incompatible with strong oxidizing agents.

CAS DataBase Reference

479-92-5(CAS DataBase Reference)

NIST Chemistry Reference

Propyphenazone(479-92-5)

EPA Substance Registry System

3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl- (479-92-5)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39

WGK Germany 

3

RTECS 

CD2800000

HS Code 

2933.39.9200

Propyphenazone Usage And Synthesis

Description

This uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known.

Chemical Properties

solid

Uses

Analgesic; antipyretic; anti-inflammatory.

Definition

ChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group.

brand name

539 grippe-dragees;Amipylo-n;Balpiren;Baukal;Caffalgina;Camoplex;Cantacin;Cerebrol;Daturmed;Degripol;Dentocaps a;Dim-antos;Dolibral;Dolo-mineuron;Dysmalgin;Ejcopyrin;Epizon;Escomen;Estesina;Fd 8;Febral;Finigripp;Grippocaps;Heaven;Infantex;Influvit;Isopronazon;Kavapyret;Kuronde;Lysadestat;Mamaslu;Milneuron;Myo-europan;Neuramin;Neuridal;Neuro-spondryl;Nodiras;Noric;Otobacid;Pfeil;Reomin;Retamex;Rheumanol;Rhinivict;Sanalgin-p;Saridon neu;Saridone;Sedospin;Servalgin;Sonotryl;Spalt;Spongamed;Stona;Synpyrin;Vivcet;Wauco-sin;Wecontrin.

World Health Organization (WHO)

Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations. See also WHO comment for aminophenazone.

Clinical Use

Propyphenazone is a derivative of phenazone and has a similar analgesic and antipyretic action. It is used as a monocompound as well as in multi-ingredient preparations.

References

Hartsen., J. Chem. Soc., 511 (1873) Mirande., Compt. rend., 168,316 (1919)

Propyphenazone(479-92-5)Related Product Information

• Poly(dimethylsiloxane)
• Dimethyl sulfoxide
• ETHANE
• Dimethyl fumarate
• Dimethyl ether
• Chlorodimethylphenylsilane
• DIANTIPYRYLMETHANE
• 5-Chlorovaleric acid
• Pralmorelin
• Dimethyl carbonate
• Diisopropyl ether
• Isoproterenol
• Diphenolic acid
• N,N-Dimethylformamide
• N,N-Dimethylaniline
• Dimethyl sulfide
• Isoproturon
• Dimethyl sulfone