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Propyphenazone

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Propyphenazone Basic information

Product Name:
Propyphenazone
Synonyms:
  • 1,2-Dihydro-4-isopropyl-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
  • 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3h-pyrazol-3-on
  • 3-Pyrazolin-5-one, 4-isopropyl-2,3-dimethyl-1-phenyl-
  • 4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
  • 4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on
  • 4-Isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
  • 4-Isopropyl-2,3-dimethyl-5-oxo-1-phenyl-3-pyrazoline
  • 4-isopropyl-antipyrin
CAS:
479-92-5
MF:
C14H18N2O
MW:
230.31
EINECS:
207-539-2
Product Categories:
  • Aromatics
  • Heterocycles
  • Active Pharmaceutical Ingredients
  • API's
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
479-92-5.mol
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Propyphenazone Chemical Properties

Melting point:
102-105°C
Boiling point:
372.3°C (rough estimate)
Density 
1.0371 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
form 
neat
pka
1.46±0.65(Predicted)
Water Solubility 
743.6g/L(25.35 ºC)
Merck 
14,7871
BRN 
204533
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
479-92-5(CAS DataBase Reference)
NIST Chemistry Reference
Propyphenazone(479-92-5)
EPA Substance Registry System
3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl- (479-92-5)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39
WGK Germany 
3
RTECS 
CD2800000
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Propyphenazone Usage And Synthesis

Description

This uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known.

Chemical Properties

solid

Uses

Analgesic; antipyretic; anti-inflammatory.

Definition

ChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group.

brand name

539 grippe-dragees;Amipylo-n;Balpiren;Baukal;Caffalgina;Camoplex;Cantacin;Cerebrol;Daturmed;Degripol;Dentocaps a;Dim-antos;Dolibral;Dolo-mineuron;Dysmalgin;Ejcopyrin;Epizon;Escomen;Estesina;Fd 8;Febral;Finigripp;Grippocaps;Heaven;Infantex;Influvit;Isopronazon;Kavapyret;Kuronde;Lysadestat;Mamaslu;Milneuron;Myo-europan;Neuramin;Neuridal;Neuro-spondryl;Nodiras;Noric;Otobacid;Pfeil;Reomin;Retamex;Rheumanol;Rhinivict;Sanalgin-p;Saridon neu;Saridone;Sedospin;Servalgin;Sonotryl;Spalt;Spongamed;Stona;Synpyrin;Vivcet;Wauco-sin;Wecontrin.

World Health Organization (WHO)

Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations. See also WHO comment for aminophenazone.

References

Hartsen., J. Chem. Soc., 511 (1873) Mirande., Compt. rend., 168,316 (1919)

PropyphenazoneSupplier

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