Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Antipyretic analgesics >  Antipyretic analgesics >  Propyphenazone

Propyphenazone

Basic information Safety Supplier Related

Propyphenazone Basic information

Product Name:
Propyphenazone
Synonyms:
  • 1,2-Dihydro-4-isopropyl-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
  • 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3h-pyrazol-3-on
  • 3-Pyrazolin-5-one, 4-isopropyl-2,3-dimethyl-1-phenyl-
  • 4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
  • 4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on
  • 4-Isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
  • 4-Isopropyl-2,3-dimethyl-5-oxo-1-phenyl-3-pyrazoline
  • 4-isopropyl-antipyrin
CAS:
479-92-5
MF:
C14H18N2O
MW:
230.31
EINECS:
207-539-2
Product Categories:
  • Aromatics
  • Heterocycles
  • Active Pharmaceutical Ingredients
  • API's
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
479-92-5.mol
More
Less

Propyphenazone Chemical Properties

Melting point:
102-105°C
Boiling point:
372.3°C (rough estimate)
Density 
1.0371 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
pka
1.46±0.65(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
743.6g/L(25.35 ºC)
Merck 
14,7871
BRN 
204533
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
479-92-5(CAS DataBase Reference)
NIST Chemistry Reference
Propyphenazone(479-92-5)
EPA Substance Registry System
3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl- (479-92-5)
More
Less

Safety Information

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39
WGK Germany 
3
RTECS 
CD2800000
HS Code 
2933.39.9200
More
Less

Propyphenazone Usage And Synthesis

Description

This uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known.

Chemical Properties

solid

Uses

Analgesic; antipyretic; anti-inflammatory.

Definition

ChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group.

brand name

539 grippe-dragees;Amipylo-n;Balpiren;Baukal;Caffalgina;Camoplex;Cantacin;Cerebrol;Daturmed;Degripol;Dentocaps a;Dim-antos;Dolibral;Dolo-mineuron;Dysmalgin;Ejcopyrin;Epizon;Escomen;Estesina;Fd 8;Febral;Finigripp;Grippocaps;Heaven;Infantex;Influvit;Isopronazon;Kavapyret;Kuronde;Lysadestat;Mamaslu;Milneuron;Myo-europan;Neuramin;Neuridal;Neuro-spondryl;Nodiras;Noric;Otobacid;Pfeil;Reomin;Retamex;Rheumanol;Rhinivict;Sanalgin-p;Saridon neu;Saridone;Sedospin;Servalgin;Sonotryl;Spalt;Spongamed;Stona;Synpyrin;Vivcet;Wauco-sin;Wecontrin.

World Health Organization (WHO)

Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations. See also WHO comment for aminophenazone.

Clinical Use

Propyphenazone is a derivative of phenazone and has a similar analgesic and antipyretic action. It is used as a monocompound as well as in multi-ingredient preparations.

References

Hartsen., J. Chem. Soc., 511 (1873) Mirande., Compt. rend., 168,316 (1919)

PropyphenazoneSupplier

Zhejiang Haisen Pharmaceutical Co., Ltd. Gold
Tel
0579-86773082
Email
sale@haisenpharma.com
Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd Gold
Tel
18207128853 18207128853
Email
3860188266@qq.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Email
Sales-CN@TCIchemicals.com
Energy Chemical
Tel
021-021-58432009 400-005-6266
Email
sales8178@energy-chemical.com