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Ethyl 6-bromoindole-2-carboxylate

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Ethyl 6-bromoindole-2-carboxylate Basic information

Product Name:
Ethyl 6-bromoindole-2-carboxylate
Synonyms:
  • 6-BROMOINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
  • 6-BROMO-2-CARBETHOXYINDOLE
  • ETHYL 6-BROMOINDOLE-2-CARBOXYLATE
  • SPECS AR-437/43285096
  • 6-BROMO-2-INDOLECARBOXYLIC METHYL ESTER
  • 6-6-BROMO-2-INDOLECARBOXYLIC
  • 6-6-BROMO-2-INDOLECARBOXYLICMETHYLESTER
  • 6-Br-ICA-OEt
CAS:
103858-53-3
MF:
C11H10BrNO2
MW:
268.11
Product Categories:
  • Indoles
  • Indole/indoline/oxindole
Mol File:
103858-53-3.mol
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Ethyl 6-bromoindole-2-carboxylate Chemical Properties

Melting point:
178-180 °C
Boiling point:
394.7±22.0 °C(Predicted)
Density 
1.554±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in acetone.
form 
Crystalline Powder
pka
14.08±0.30(Predicted)
color 
White
CAS DataBase Reference
103858-53-3(CAS DataBase Reference)
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Safety Information

Risk Statements 
20/21/22
Safety Statements 
36/37
HazardClass 
IRRITANT
HS Code 
29339900
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Ethyl 6-bromoindole-2-carboxylate Usage And Synthesis

Chemical Properties

White solid

Synthesis

In a 250mL three-necked flask, add 80mL of ethanol and 7.2g (40mmol) of 6-bromo-2-indolecarboxylic acid, slowly drop 1.0mL of concentrated sulfuric acid at room temperature and reflux for 30h (TLC tracking). After the reaction, concentrate to 30mL and pour into 60mL of water, extract twice with 20mL of ether, wash the ether layer once with 5% sodium carbonate solution, and then wash with water until neutral, dry with anhydrous magnesium sulfate, and evaporate the ether to obtain 7.7g of yellow to brown powder Ethyl 6-bromoindole-2-carboxylate, with a yield of 92.3%.

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