GP ANTAGONIST-2A Chemical Properties

storage temp. 

−20°C

form 

lyophilized solid

Water Solubility 

water: 25mg/mL

Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Trp-Met-NH2

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

GP ANTAGONIST-2A Usage And Synthesis

Uses

[D-Trp7,9,10]-Substance P is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors[1].

Biological Activity

Cell permeable: no', 'Primary Target
Inhibits the activation of Gq by M1-muscarinic cholinergic receptors', 'Product does not compete with ATP.', 'Reversible: no

References

[1] Eardley D, et al. Both substance P agonists and antagonists inhibit ion conductance through nicotinic acetylcholine receptors on PC12 cells. Eur J Pharmacol. 1985;114(1):101-104. DOI:10.1016/0014-2999(85)90529-1
[2] Mukai H, et al. G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J Biol Chem. 1992;267(23):16237-16243. PMID:1379592

GP ANTAGONIST-2A(89430-38-6)Related Product Information

• D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2
• GP ANTAGONIST-2
• GP ANTAGONIST-2A