5-NITRO-2-PHENYL-1H-INDOLE Chemical Properties

Melting point:

234-235 °C

Boiling point:

477.5±25.0 °C(Predicted)

Density 

1.330±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

15.05±0.30(Predicted)

5-NITRO-2-PHENYL-1H-INDOLE Usage And Synthesis

Uses

INF55 is a NoA multidrug resistance pump inhibitor with the activity of inhibiting the NoA pump. The heterocomplex formed by INF55 combined with berberine shows the potential to combat the resistance of bacterial compounds. INF55 can enhance the antibacterial activity of berberine by reducing its efflux. The structural variants of INF55 can show different NoA inhibitory activities, thereby affecting the antibacterial effect of its corresponding heterocomplexes. Different derivatives of INF55 show similar activity in terms of antibacterial dose and effectiveness[1].

References

[1] On the Mechanism of Berberine-INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials