BEPRIDIL Chemical Properties

Boiling point:

bp0.1 184°; bp0.5 192°

Density 

1.0392 (rough estimate)

refractive index 

nD20 1.5538

storage temp. 

2-8°C

pka

9.21±0.20(Predicted)

Water Solubility 

7.43g/L(37 ºC)

BEPRIDIL Usage And Synthesis

Uses

Bepridil is protective against Ebola virus. Bepridil is used in biological study of shortening of electromechnical window in ketamine/xylazine-anesthetized guinea pig model improved QTc interval prolongation and assessed pro-arrhythmic risk during early drug development. Bepridil is also used in therapeutic use in novel high/low solubility classification methods for new molecular entities.

Definition

ChEBI: A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.

Enzyme inhibitor

This substituted pyrrolidine (FWfree-base = 366.55 g/mol) is a calcium channel blocker that inhibits the Na+ /Ca2+ exchange, exhibiting antiarrhythmic, antianginal, and vasodilatory properties. Bepridil inhibits the growth of certain brain tumors in vitro. Bepridil also binds to troponin C. Target(s): Ca2+ channels; ATP-sensitive K+ channels; Na+ -activated K+ channels.

BEPRIDIL(64706-54-3)Related Product Information

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