Aselizumab
Aselizumab Basic information
- Product Name:
- Aselizumab
- Synonyms:
-
- Aselizumab
- Aselizumab [inn]
- Bnp 001
- Hudreg-55
- Immunoglobulin G4, anti-(L-selectin) (human-mouse monoclonal hudreg-55 heavy chain), disulfide with human-mouse monoclonal hudreg-55 light chain, dimer
- Research Grade Aselizumab (DHD03301)
- Research Grade Teneliximab
- Research Grade Aselizumab
- CAS:
- 395639-53-9
- MW:
- 0
- Mol File:
- Mol File
Aselizumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
Aselizumab Usage And Synthesis
Uses
Aselizumab (HuDreg-55) is an humanized IgG4 mAb against L-selectin. However, L-selectin (CD62L) is a cell adhesion molecule expressed on circulating neutrophils. It regulates migrating cells to chemotaxis towards the site of injury. Aselizumab may be account for a high rate of infections and leucopenia after truma[1][2].
in vivo
Aselizumab (10 mg/kg; i.v.; single dose) shows terminal elimination half-lives at 12.0 days in rhesus monkeys[3].
References
[1] Seekamp A, et al. The effect of anti-L-selectin (aselizumab) in multiple traumatized patients--results of a phase II clinical trial. Crit Care Med. 2004 Oct;32(10):2021-8. DOI:10.1097/01.ccm.0000142396.59236.f3
[2] Rahman I, et al. L-selectin regulates human neutrophil transendothelial migration. J Cell Sci. 2021 Feb 8;134(3):jcs250340. DOI:10.1242/jcs.250340
[3] Co MS, et al. Properties and pharmacokinetics of two humanized antibodies specific for L-selectin. Immunotechnology. 1999 Mar;4(3-4):253-66. DOI:10.1016/s1380-2933(98)00024-4
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