Medetomidine hydrochloride Chemical Properties

Melting point:

164-166°C

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

Acetonitrile (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

InChI

InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H

InChIKey

VPNGEIHDPSLNMU-UHFFFAOYSA-N

SMILES

C(C1N=CNC=1)(C1C=CC=C(C)C=1C)C.Cl

Medetomidine hydrochloride Usage And Synthesis

Description

Medetomidine hydrochloride is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). It is an imidazole compound. Medetomidine hydrochloride shows greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). In addition, it influences the adrenergic system by mimicking the action of adrenergic neurotransmitters.

Chemical Properties

White Solid

Uses

Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor

Uses

An α2-Adrenergic agonist. Sedative; analgesic.

Definition

ChEBI: Medetomidine hydrochloride is a hydrochloride.

Biological Activity

medetomidine is a selective α2-adrenoceptor agonist, with ki of 1.08 nm, exhibts 1620-fold selectivity over α1-adrenoceptor.

Side effects

Medetomidine hydrochloride is an alpha-2 adrenoreceptor agonist. Symptoms after absorption may involve clinical effects, including dose dependent sedation, respiratory depression, bradycardia, hypotension, a dry mouth, and hyperglycaemia. Ventricular arrhythmias have also been reported. Respiratory and haemodynamic symptoms should be treated symptomatically.

storage

Desiccate at RT

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