Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Inhibitors >  Proteases >  HIV Protease Inhibitors >  Nelfinavir mesylate

Nelfinavir mesylate

Basic information Safety Supplier Related

Nelfinavir mesylate Basic information

Product Name:
Nelfinavir mesylate
Synonyms:
  • 8a-beta))-a-betmonomethanesulfonate(salt)
  • droxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-,(3s-(2(2,s*,3s*),3-alpha,4
  • viracept
  • 3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-, (3S,4aS,8aS)-, methanesulfonate (1:1)
  • (3S,4AS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl
  • NELFINAVIR MESYLATE
  • AG-1343
  • (3s,4as,8as)-n-(1,1-dimethylethyl)decahydro-2-[(2r,3r)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide mesylate
CAS:
159989-65-8
MF:
C33H49N3O7S2
MW:
663.89
Product Categories:
  • Pfizer compounds
  • peptides
  • Anti-virals
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Non-nucleoside Reverse Transcriptase
  • Active Pharmaceutical Ingredients
  • Anti-viral Compounds
  • Pharmaceuticals
  • Nelfinavir
Mol File:
159989-65-8.mol
More
Less

Nelfinavir mesylate Chemical Properties

Melting point:
131-135°C
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO: ≥2mg/mL
pka
pKa -1.20(at 25℃)
form 
powder
color 
white to off-white
Water Solubility 
4.5g/L(temperature not stated)
Merck 
14,6443
InChIKey
NQHXCOAXSHGTIA-SKXNDZRYSA-N
CAS DataBase Reference
159989-65-8(CAS DataBase Reference)
More
Less

Safety Information

WGK Germany 
3
RTECS 
NW6995333
HS Code 
29334900
Hazardous Substances Data
159989-65-8(Hazardous Substances Data)
More
Less

Nelfinavir mesylate Usage And Synthesis

Description

Viracept was launched in the US as an orally-available, non-peptidic HIV protease inhibitor. It is prepared in an eight step synthesis beginning with N- (benzyloxycarbonyl)-L-serine β-lactone. The HIV protease inhibitory activity blocks the processing of gag and gagpol polyproteins that are required for viral maturation. It was discovered based on an experimentally derived 3D-structure of HIV-1 protease. Viracept has a high oral bioavailability, lacks toxicity, and has a resistance profile different from other protease inhibitors. Viracept with ziduvudine and larnivudine generated a 98% mean reduction from baseline in viral load after 24 weeks compared to ziduvudine and larnivudine alone. Viracept also had better CD4 counts and is available in adult and pediatric formulations.

Chemical Properties

White Powder

Originator

Agouron (US)

Uses

An antiviral. HIV protease inhibitor.

Definition

ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of nelfinavir and methanesulfonic acid. It is used for treatment of HIV and also exhibits some anticancer properties.

brand name

Viracept (Agouron).

Biological Activity

Orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (K i = 2 nM) in vitro .

Nelfinavir mesylateSupplier

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Email
jkinfo@jkchemical.com;market6@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Email
3bsc@sina.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Email
sj_scrc@sinopharm.com