VALERIC ACID HYDRAZIDE Chemical Properties

Melting point:

54-57°C

Boiling point:

261℃

Density 

0.962

Flash point:

111℃

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

13.54±0.18(Predicted)

BRN 

1744747

CAS DataBase Reference

38291-82-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

UN1325

HazardClass 

IRRITANT

MSDS

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VALERIC ACID HYDRAZIDE Usage And Synthesis

Uses

Valeric acid hydrazide is an amino derivative and can be used as an organic reagent.

Synthesis

General procedure for the synthesis of valerylhydrazine from ethyl valerate: hydrazine hydrate (783 μL) was added to a solution of ethanol (20 mL) containing ethyl valerate (420 mg, 3.22 mmol). The resulting solution was heated to reflux for 12 hours. Upon completion of the reaction, the mixture was kept warm and the volatiles were removed under vacuum. The resulting valerylhydrazine was used for subsequent reactions without further purification. Yield: 99%. 1H NMR (400 MHz, CDCl3) δ: 7.25 (s, 1H), 2.15-2.11 (d, J = 7.6 Hz, 2H), 1.64-1.57 (m, 2H), 1.37-1.28 (m, 2H), 0.92-0.88 (t, J = 7.2 Hz, 3H) ppm.

References

[1] Patent: WO2016/128541, 2016, A1. Location in patent: Page/Page column 101
[2] Patent: WO2017/162834, 2017, A1. Location in patent: Page/Page column 93

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