2-Aminothiazole Chemical Properties

Melting point:

91-93 °C (lit.)

Boiling point:

117 °C (15.002 mmHg)

Density 

1.241 (estimate)

vapor pressure 

<1 hPa (20 °C)

refractive index 

1.5300 (estimate)

Flash point:

117°C/15mm

storage temp. 

Store below +30°C.

solubility 

1 M HCl: soluble50mg/mL, clear (dark yellow-brown)

pka

5.36(at 20℃)

form 

Crystalline Powder, Grains, Lumps or Flakes

color 

Brown

PH

9.6 (100g/l, H2O, 20℃)

Water Solubility 

100 g/L (20 ºC)

Merck 

14,479

BRN 

105738

InChIKey

RAIPHJJURHTUIC-UHFFFAOYSA-N

LogP

0.380

CAS DataBase Reference

96-50-4(CAS DataBase Reference)

NIST Chemistry Reference

2-Aminothiazole(96-50-4)

EPA Substance Registry System

2-Aminothiazole (96-50-4)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36-36/37-20/21/22

Safety Statements 

26-36/37-39-36

WGK Germany 

3

RTECS 

XJ2100000

F 

8-9

Autoignition Temperature

600 °C

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29341000

Toxicity

LD50 orally in Rabbit: 480 mg/kg

MSDS

• Language:English Provider:2-Aminothiazole
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Aminothiazole Usage And Synthesis

Chemical Properties

brown crystalline powder, grains, lumps or flakes

Uses

antithyroid agent

Uses

Usually used in the synthesis of 2-aminothiazole-modified silica gel，and aslo used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation.

Uses

2-Aminothiazole is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds.

Definition

ChEBI: A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2.

Synthesis Reference(s)

Journal of the American Chemical Society, 76, p. 693, 1954 DOI: 10.1021/ja01632a016

General Description

Light brown crystals or brown granular solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2-Aminothiazole reacts violently when nitrated with nitric or nitric-sulfuric acids. 2-Aminothiazole is also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides.

Fire Hazard

Flash point data for 2-Aminothiazole are not available; however, 2-Aminothiazole is probably combustible.

Biochem/physiol Actions

2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders.

Safety Profile

Poison by ingestion andintraperitoneal routes. Mutation data reported.Spontaneous ignition occurs at 100°. Mixtures with nitricacid or nitric acid + sulfuric acid explode on heating.Incompatible with HNO3 and H2SO4. When heated todecomposition it emi

Purification Methods

It crystallises from pet ether (b 100-120o), or EtOH. [Beilstein 27 III/IV 4574.]

2-Aminothiazole (96-50-4)Related Product Information

• Fosthiazate
• 2-Mercaptobenzothiazole
• 2-Methyl-4-isothiazolin-3-one
• Benzothiazole
• MTT
• Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
• Isothiazole
• 2-Benzothiazolamine
• 2-(2-THIAZOLYLAZO)-P-CRESOL
• 4-(2-THIAZOLYLAZO)RESORCINOL
• 2-Amino-6-nitrobenzothiazole
• 2-Amino-6-methoxybenzothiazole
• 2-AMINO-5-(4-NITROPHENYLSULFONYL)THIAZOLE
• 2-AMINO-4-PHENYL-5-N-TETRADECYLTHIAZOLE
• 2-CHLOROMETHYL-3,4-DIMETHOXY PYRIDINE HYDROCHLORIDE
• 2-Amino-4-methylthiazole
• 2-Amino-6-ethoxybenzothiazole
• Phthalylsulfathiazole