Kaempferol 3-arabinofuranoside CAS#: 5041-67-8

Kaempferol 3-arabinofuranoside Basic information

Product Name:

Kaempferol 3-arabinofuranoside

Synonyms:

3-(α-L-Arabinofuranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
3-[(α-L-Arabinofuranosyl)oxy]-4',5,7-trihydroxyflavone
Juglanin
Juglanin【Juglans】
Kaempferol 3-arabinofuranoside
4H-1-Benzopyran-4-one,3-(a-L-arabinofuranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
Kaempferol 3-arabinoside
Kaempferol 3-O-alpha-L-arabinofuranoside

CAS:

5041-67-8

MF:

C20H18O10

MW:

418.35

Mol File:

5041-67-8.mol

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Kaempferol 3-arabinofuranoside Chemical Properties

Melting point:: 230-231℃ (ethanol )
Boiling point:: 803.5±65.0 °C(Predicted)
Density: 1.76±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Methanol : 16.67 mg/mL (39.85 mM)
form: Solid
pka: 6.20±0.40(Predicted)
color: White to yellow
InChI: InChI=1/C20H18O10/c21-7-13-15(25)17(27)20(29-13)30-19-16(26)14-11(24)5-10(23)6-12(14)28-18(19)8-1-3-9(22)4-2-8/h1-6,13,15,17,20-25,27H,7H2/t13-,15-,17+,20?/s3
InChIKey: POQICXMTUPVZMX-XQAOVFCONA-N
SMILES: C1(C2=CC=C(O)C=C2)OC2=C(C(=CC(=C2)O)O)C(=O)C=1OC1O[C@H](CO)[C@@H](O)[C@@H]1O |&1:23,26,28,r|

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Safety Information

HS Code: 2933998090

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Kaempferol 3-arabinofuranoside Usage And Synthesis

Uses

Juglanin inhibits the proliferation of breast cancer cell in a dose- and time-dependent manner and presents less cytotoxic against the normal cells. It is a JNK activator.

Definition

ChEBI: Kaempferol 3-arabinofuranoside is a member of flavonoids and a glycoside.

in vivo

Juglanin (10-20 mg/kg, i.p., daily, 7 days) inhibits growth of human breast cancer xenograft in a tumor-transplanted mouse model^[1].
Juglanin (10-30 mg/kg, i.p., 5 times weekly) ameliorates neuroinflammation-related memory impairment and neurodegeneration through impeding TLR4/NF-κB in C57BL6 male mice^[2].
Juglanin (80 mg/kg, i.g., daily, 21 days) protects against bleomycin (BLM, HY-108345)-induced lung injury by inhibiting fibrosis in C57BL/6 male mice^[3].

Animal Model:	Tumor-transplanted mouse model ^[1]
Dosage:	10-20 mg/kg
Administration:	Intraperitoneal injection (i.p.), daily, 7 days
Result:	Increased levels of cleaved Caspase-9 and Caspase-3, LC3BI, LC3BII and phosphorylated JNK. Increased dead cells and apoptosis proportion in juglanin-treated tumor tissues. Increase in mean areas that stained positively cleaved Caspase-3 in juglanin-treated tumor tissues.

Animal Model:	C57BL6 male mice^[2]
Dosage:	10-30 mg/kg
Administration:	Intraperitoneal injection (i.p.), 5 times weekly
Result:	Increased number of platform crossings and expanded time in target quadrant. Decreased the expression level of α-synuclein, pro-inflammatory cytokines (IL-1β, TNF-α, IL-18 and COX-2), TLR-4, MyD88, CD14, Aβ, phosphorylation of Tau, Ibal and neurotrophic factor (BDNF). Reversed LPS-triggered effect on synaptic markers, up-regulating the expression of SYP, PSD-95 and SNAP-25. Restored TH levels in the hippocampus of mice in a dose-dependent manner. Decreased p-IKKα, p-IκBα and p-NF-κB levels combinated with LPS. Decreased the GFAP-positive cells.

Animal Model:	C57BL/6 male mice^[3]
Dosage:	80 mg/kg
Administration:	i.g., daily, 1-21 days
Result:	Improved the survial rate of the BLM (HY-108345)-treated mice. Decreased the expression of BALF, CXCL1, IL-6, TNF-α, MPO activity, TGF-β1, and its down-streaming proteins (fibronectin/MMP-9/α-SMA/collagen I) Reduced the number of total cells, neutrophils and macrophages in BALF.

IC 50

JNK

Kaempferol 3-arabinofuranosideSupplier

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Email: y.liu@mail.biobiopha.com

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Email: cwb1@biopurify.cn

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Email: tauto@tautobiotech.com

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Email: sales@reading-chemicals.com

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Email: sales@jhechem.com

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