Heptafluorobutyric anhydride Chemical Properties

Melting point:

−43 °C(lit.)

Boiling point:

108-110 °C(lit.)

Density 

1.674 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.287(lit.)

Flash point:

None

storage temp. 

room temp

solubility 

Miscible with halogenated solvents. Immiscible with polar solvents.

form 

Liquid

Specific Gravity

1.653

color 

Colorless to Almost colorless

Water Solubility 

REACTS

Sensitive 

Hygroscopic

BRN 

856036

Stability:

Moisture Sensitive

InChIKey

UFFSXJKVKBQEHC-UHFFFAOYSA-N

CAS DataBase Reference

336-59-4(CAS DataBase Reference)

NIST Chemistry Reference

Heptafluorobutyric anhydride(336-59-4)

EPA Substance Registry System

Heptafluorobutyric anhydride (336-59-4)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

F 

10-21

Hazard Note 

Corrosive/Hygroscopic

TSCA 

T

HazardClass 

8

PackingGroup 

III

HS Code 

29159080

MSDS

• Language:English Provider:Perfluorobutyric anhydride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Heptafluorobutyric anhydride Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

Heptafluorobutyric anhydride (HFAA) is frequently used as an acylating agent for the derivatization of primary and secondary amines (Walle and Ehrsson, 1971). Commercially available Heptafluorobutyric anhydride may afford low yields of the derivative due to the presence of Heptafluorobutyric acid (Moodie et al., 1985). This contaminant may be removed by ditillation over phosphorus pentoxide (Walle and Ehrsson, 1970).
HFAA is used to increase volatility of an analyte, and to introduce fluorine atoms for better detection limits in gas chromatography applications.
suzuki reaction

Uses

Heptafluorobutyric anhydride is used as a derivatization reagent for gas chromatography - mass mass spectrometry analysis of the stereoisomer content of synthetic peptides. It is a GC derivatizing agent used to prepare volatile derivatives of amino acids and other biologically active compounds.

Uses

As a GC derivatizing agent, Heptafluorobutyric anhydride is used to prepare volatile derivatives of amino acids and other biologically active compounds.

Definition

ChEBI: An acyclic carboxylic anhydride that is perfluorinated butyric anhydride. It is used as a derivatising reagent for gas chromatographic analyses.

General Description

Heptafluorobutyric anhydride is a perfluoroacylated acylation reagent, that forms stable, volatile derivatives with alcohols, amines, and phenols. It is majorly used to prepare electron-capturing derivatives for GC/electron capture detection. It is generally used with an acid scavenger, to help drive the reaction to completion and to prevent column damage from acidic by-products of the derivatization reaction. It is also used for the frequent testing of drugs of abuse such as, amphetamines and phencyclidine by GC-MS technique.

Heptafluorobutyric anhydride(336-59-4)Related Product Information

• Isatoic Anhydride
• Flutamide
• Trifluoromethanesulfonic anhydride
• Isobutyric anhydride
• Succinic anhydride
• Glutaric anhydride
• Erythromycin Estolate
• Butyric anhydride
• Phthalic anhydride
• CIS-BUTENEDIOIC ANHYDRIDE
• N-BUTYL HEPTAFLUOROBUTYRATE
• Pentafluoroethane
• 1,1,1,2,3,3-HEXAFLUOROPROPANE
• Propyl acetate
• 1-FLUOROPROPANE
• METHYL HEPTAFLUOROBUTYRATE
• 2,2-DIFLUOROBUTYRIC ACID
• Acetic anhydride