Ganoderenic acid D
Ganoderenic acid D Basic information
- Product Name:
- Ganoderenic acid D
- Synonyms:
-
- (20E)-7β-Hydroxy-3,11,15,23-tetraoxo-5α-lanosta-8,20(22)-dien-26-oic acid
- (20E)-7β-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-diene-26-oic acid
- (7beta,20E)-7-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-dien-26-oic acid
- Ganoderenic acid d
- Apoptosis,Inhibitor,inhibit,Ganoderenic acid D
- (E)-6-((5R,7S,10S,13R,14R,17R)-7-Hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-4-oxohept-5-enoic acid
- Lanosta-8,20(22)-dien-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β,20E)-
- CAS:
- 100665-43-8
- MF:
- C30H40O7
- MW:
- 512.6344
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 100665-43-8.mol
Ganoderenic acid D Chemical Properties
- Melting point:
- 218-220℃
- Boiling point:
- 702.3±60.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 4.63±0.23(Predicted)
- color
- White to off-white
Ganoderenic acid D Usage And Synthesis
Uses
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. It inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells. It also induces HeLa human cervical carcinoma apoptosis.
Definition
ChEBI: Ganoderenic acid D is a triterpenoid.
Biological Activity
Ganoderenic acid D is a triterpenoid originally isolated from G. lucidum and has diverse biological activities. It inhibits angiotensin-converting enzyme (ACE; IC50 = 734 μM). Ganoderenic acid D is cytotoxic to HepG2 liver, HeLa cervical, and Caco-2 colon cancer cells (IC50s = 0.14, 0.18, and 0.26 mg/ml, respectively). It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50 = 13.77 μM).
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Ganoderenic acid D(100665-43-8)Related Product Information
- LUCIDENIC ACID D2(SH)
- (5alpha,7beta)-7-Hydroxy-4,4,14-trimethyl-3,11,15-trioxo-chola-8,20-dien-24-oic acid
- Lucidenic acid L
- 23S-hydroxyl-11,15-dioxo-ganoderic acid DM
- Lucidenic acid B
- Lucidenic acid C
- Ganoderenic acid E
- VIGABATRIN
- ECHINOCYSTIC ACID
- Epmedin B
- ASARININ
- MOLLUGIN
- Paederosidic acid
- Jujuboside B
- Astragaloside II
- Ganoderenic acid B
- (20E)-3β,7β,15α-Trihydroxy-11,23-dioxo-5α-lanosta-8,20(22)-dien-26-oic acid
- ganoderenic acid A