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Ganoderenic acid D

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Ganoderenic acid D Basic information

Product Name:
Ganoderenic acid D
Synonyms:
  • (20E)-7β-Hydroxy-3,11,15,23-tetraoxo-5α-lanosta-8,20(22)-dien-26-oic acid
  • (20E)-7β-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-diene-26-oic acid
  • (7beta,20E)-7-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-dien-26-oic acid
  • Ganoderenic acid d
  • Apoptosis,Inhibitor,inhibit,Ganoderenic acid D
  • (E)-6-((5R,7S,10S,13R,14R,17R)-7-Hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-4-oxohept-5-enoic acid
  • Lanosta-8,20(22)-dien-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β,20E)-
CAS:
100665-43-8
MF:
C30H40O7
MW:
512.6344
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
100665-43-8.mol
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Ganoderenic acid D Chemical Properties

Melting point:
218-220℃
Boiling point:
702.3±60.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
4.63±0.23(Predicted)
color 
White to off-white
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Ganoderenic acid D Usage And Synthesis

Uses

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. It inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells. It also induces HeLa human cervical carcinoma apoptosis.

Definition

ChEBI: Ganoderenic acid D is a triterpenoid.

Biological Activity

Ganoderenic acid D is a triterpenoid originally isolated from G. lucidum and has diverse biological activities. It inhibits angiotensin-converting enzyme (ACE; IC50 = 734 μM). Ganoderenic acid D is cytotoxic to HepG2 liver, HeLa cervical, and Caco-2 colon cancer cells (IC50s = 0.14, 0.18, and 0.26 mg/ml, respectively). It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50 = 13.77 μM).

Ganoderenic acid DSupplier

ShangHai YuanYe Biotechnology Co., Ltd.
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021-61312847 13636370518
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Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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Cheng Du Pufeide Biotechnology Co., Ltd.
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028-82610909 13388174823
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
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Shanghai Aspire Biological Technology Co., Ltd.
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021-61317773
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