2-Phenyl-3-methylquinoxaline Chemical Properties

Melting point:

57-58 °C

Boiling point:

165 °C(Press: 0.5 Torr)

Density 

1.149±0.06 g/cm3(Predicted)

solubility 

DMF: 25 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml; Ethanol: 25 mg/ml

form 

A crystalline solid

pka

0?+-.0.48(Predicted)

2-Phenyl-3-methylquinoxaline Usage And Synthesis

Description

2-phenyl-3-methyl-Quinoxaline is a synthetic intermediate useful for pharmaceutical synthesis.

Uses

2-Methyl-3-phenylquinoxaline (compound 38) is a potent platelet-derived growth factor receptor tyrosine kinase (PDGF-RTK) inhibitor with modest inhibitory activity against PDGFR kinase in intact cells (IC50 greater than 100 μM)[1].

References

[1] Gazit A, et al. Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: structure? activity relationships in quinoxalines, quinolines, and indole tyrphostins[J]. Journal of medicinal chemistry, 1996, 39(11): 2170-2177. DOI:10.1021/jm950727b